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Title

THE EFFECTS OF TOCOTRIENOL-ENRICHED CANOLA OIL ON INFLAMMATION, NITROSATIVE STRESS AND URINARY MICROALBUMIN IN PATIENTS WITH TYPE-2 DIABETES: ARANDOMIZED DOUBLE-BLIND CLINICAL TRIAL

Pages

  1-9

Abstract

 Background and Objective: TOCOTRIENOLS have been demonstrated to play a significant role in preventing diabetic nephropathy due to their immunologic and inflammatory properties.The objective of this study was to determine the effects of a daily intake of canola oil enriched with 200 mg tocotrienol (T3) for 8 weeks on NITROSATIVE STRESS, INFLAMMATION and urinary microalbumin in type-2 diabetic patients.Materials and Methods: This clinical trial was conducted on 50 patients with TYPE-2 DIABETES MELLITUS (fasting blood sugar>126 mg/dl) randomly divided into 2 groups of 25 each to receive, daily for 8 weeks, either 15 ml T3-enriched canola oil (200mg T3; experimental group) or 15 ml pure canola oil (control group). Initial and final blood samples were collected to measureserum hs-CRP and nitric oxide (NO) levels, and 24-hr urine samples to measure urinary volume and microalbumin and creatinine levels. Physical activity levels, anthropometric parameters and nutrients intakes were determined before and after intervention and compared between the 2 groups.Results: T3-enriched canola oil brought about statistically significant reductions in urinary microalbumin (p=0.004) and hs-CRP (p=0.003). Also, at the end of the study, the intervention group had significantly lower serum hs-CRP and urinary microalbumin than the control group. A nonsignificant decrease was observed in the serum NO level in the T3 group.Conclusion: Based on the findings it may be concluded that TOCOTRIENOLS can improve the inflammatory status and prevent diabetic nephropathy. However, its effect on NITROSATIVE STRESS needs furher investigation.

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    APA: Copy

    HAGHIGHAT, N., VAFA, M.R., EGHTESADI, SH., HEIDARI, I., & HOSEINI, A.F.. (2013). THE EFFECTS OF TOCOTRIENOL-ENRICHED CANOLA OIL ON INFLAMMATION, NITROSATIVE STRESS AND URINARY MICROALBUMIN IN PATIENTS WITH TYPE-2 DIABETES: ARANDOMIZED DOUBLE-BLIND CLINICAL TRIAL. JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY, 8(1), 1-9. SID. https://sid.ir/paper/393869/en

    Vancouver: Copy

    HAGHIGHAT N., VAFA M.R., EGHTESADI SH., HEIDARI I., HOSEINI A.F.. THE EFFECTS OF TOCOTRIENOL-ENRICHED CANOLA OIL ON INFLAMMATION, NITROSATIVE STRESS AND URINARY MICROALBUMIN IN PATIENTS WITH TYPE-2 DIABETES: ARANDOMIZED DOUBLE-BLIND CLINICAL TRIAL. JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY[Internet]. 2013;8(1):1-9. Available from: https://sid.ir/paper/393869/en

    IEEE: Copy

    N. HAGHIGHAT, M.R. VAFA, SH. EGHTESADI, I. HEIDARI, and A.F. HOSEINI, “THE EFFECTS OF TOCOTRIENOL-ENRICHED CANOLA OIL ON INFLAMMATION, NITROSATIVE STRESS AND URINARY MICROALBUMIN IN PATIENTS WITH TYPE-2 DIABETES: ARANDOMIZED DOUBLE-BLIND CLINICAL TRIAL,” JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY, vol. 8, no. 1, pp. 1–9, 2013, [Online]. Available: https://sid.ir/paper/393869/en

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