The effects of Silibinin on nitrosative stress and matrix metalloproteinase-9 expression in Balb/c mice with breast cancer tumor

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Soleimani Farhad; SHARIFI RASOUL; MAHMOODI MINOO; KASSAEE SEYED MEHRDAD

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Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2020 | Volume:42 | Issue:5 Page(s): 529-536

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Title

The effects of Silibinin on nitrosative stress and matrix metalloproteinase-9 expression in Balb/c mice with breast cancer tumor

Author(s)

Soleimani Farhad | SHARIFI RASOUL | MAHMOODI MINOO | KASSAEE SEYED MEHRDAD | Issue Writer Certificate

Keywords

SilibininQ1

Nitrosative StressQ1

Matrix MetalloproteinaseQ1

Breast CancerQ2

Abstract

Background: Among the factors associated with cancer are the Nitrosative Stress and increased expression of some Matrix Metalloproteinase (MMP). Silibinin has an anti-tumor effect, therefore, the present study evaluates the effects of slibinin on Nitrosative Stress indices and Matrix Metalloproteinase-9 (MMP-9) expression in the animal models of Breast Cancer. Methods: In this study, 48 Balb/c mice were divided into 6 groups (each group contains 8 mouse): healthy ( control and cancer ) and treatment groups: treatment groups included cancerous mice which receiving 20 mg, 40 mg and 80 mg of Silibinin for 3 weeks. In order to induce cancer, 4T1 cell line was used. After enrolling serum and breast tumor samples, NO level and MMP-9 expression in breast tumor biopsy were evaluated. Data were analyzed using one-way ANOVA, Kruskal-Wallis and T-test (p <0. 05). Results: The results revealed that the use 80 mg of Silibinin resulted in significantly decreased in NO level in cancerous mice(170. 88± 15. 42μ M/ml) compared with untreated cancerous mice(190. 38± 21. 19 μ M/ml) (p=0. 05). Furthermore, the use of three dose of Silibinin led to a non-significant reduction of MMP-9 in the treatment group compared to untreated cancerous mice. Conclusion: Silibinin treatment has been shown to improve Nitrosative Stress in Breast Cancer mice.

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APA: Copy

Soleimani, Farhad, SHARIFI, RASOUL, MAHMOODI, MINOO, & KASSAEE, SEYED MEHRDAD. (2020). The effects of Silibinin on nitrosative stress and matrix metalloproteinase-9 expression in Balb/c mice with breast cancer tumor. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 42(5 ), 529-536. SID. https://sid.ir/paper/392193/en

Vancouver: Copy

Soleimani Farhad, SHARIFI RASOUL, MAHMOODI MINOO, KASSAEE SEYED MEHRDAD. The effects of Silibinin on nitrosative stress and matrix metalloproteinase-9 expression in Balb/c mice with breast cancer tumor. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;42(5 ):529-536. Available from: https://sid.ir/paper/392193/en

IEEE: Copy

Farhad Soleimani, RASOUL SHARIFI, MINOO MAHMOODI, and SEYED MEHRDAD KASSAEE, “The effects of Silibinin on nitrosative stress and matrix metalloproteinase-9 expression in Balb/c mice with breast cancer tumor,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 42, no. 5 , pp. 529–536, 2020, [Online]. Available: https://sid.ir/paper/392193/en

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