THE ULTRASTRUCTURAL STUDY OF OOCYTE AND ZONA PELLUCIDA IN OVARIAN FOLLICLES OF UNTREATED AND AND METFORMIN-TREATED DIABETIC RATS SUBSEQUENT TO INDUCTION OF EXPERIMENTAL DIABETES

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POURNAGHI POUYA; SADRKHANLOO RAJAB ALI; HASANZADEH SHAPOUR; FARSHID AMIR ABBAS

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Journal: Tehran University Medical Journal Year:2011 | Volume:69 | Issue:6 Page(s): 366-373

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Title

THE ULTRASTRUCTURAL STUDY OF OOCYTE AND ZONA PELLUCIDA IN OVARIAN FOLLICLES OF UNTREATED AND AND METFORMIN-TREATED DIABETIC RATS SUBSEQUENT TO INDUCTION OF EXPERIMENTAL DIABETES

Author(s)

POURNAGHI POUYA | SADRKHANLOO RAJAB ALI | HASANZADEH SHAPOUR | FARSHID AMIR ABBAS | Issue Writer Certificate

Keywords

DIABETESQ2

METFORMINQ3

OOCYTEQ2

OVARYQ2

RATQ2

ZONA PELLUCIDAQ3

Abstract

Background: DIABETES is a metabolic disorder affecting the whole body systems including the female reproductive organs. Moreover, DIABETES is an important cause of infertility. METFORMIN is commonly used to control hyperglycemia in patients with DIABETES. This study was done to evaluate the ultra structural changes of ovarian follicles in diabetic RATs and their response to METFORMIN.Methods: Thirty-six adult Sprague-Dawley female RATs (170-210 g) were studied in three groups (Control, diabetic and METFORMIN-treated RATs). In the second and third groups, DIABETES was induced by injection of streptozotocin (45 mg/kg). The RATs in the third group were later treated by METFORMIN monohydrochloride (100 mg/kg). At the end of the experiment, RATs were sacrificed and their right ovaries were observed under transmission electron microscope. Quantitative data were analyzed by student t-test in SAS software.Results: In comparison with the control group, significant decreases in ZONA PELLUCIDA thickness and the mean number of microvilli were observed (respectively, P<0.01 and P<0.001) in diabetic RATs. Significant decreases in ZONA PELLUCIDA thickness were also observed in METFORMIN-treated RATs (P<0.05) but changes in the number of microvilli were non-significant. The number of organelles in OOCYTE cytoplasm was higher and they were natural or natural-looking in METFORMIN-treated RATs versus the diabetic ones. Reduction in the number of mitochondria and their ballooning cristae were of the most noticeable changes in diabetic RATs.Conclusion: DIABETES decreases the number of microvilli and OOCYTE organelles and diminishes ZONA PELLUCIDA thickness leading to structural changes in the organelles but METFORMIN could improve the aforesaid conditions.

Cites

INVESTIGATION THE EFFECT OF CURCUMIN ON THE HORMONES OF PITUITARY-OVARIAN AXIS IN ALLOXAN-INDUCED DIABETIC RATS

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APA: Copy

POURNAGHI, POUYA, SADRKHANLOO, RAJAB ALI, HASANZADEH, SHAPOUR, & FARSHID, AMIR ABBAS. (2011). THE ULTRASTRUCTURAL STUDY OF OOCYTE AND ZONA PELLUCIDA IN OVARIAN FOLLICLES OF UNTREATED AND AND METFORMIN-TREATED DIABETIC RATS SUBSEQUENT TO INDUCTION OF EXPERIMENTAL DIABETES. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 69(6), 366-373. SID. https://sid.ir/paper/39427/en

Vancouver: Copy

POURNAGHI POUYA, SADRKHANLOO RAJAB ALI, HASANZADEH SHAPOUR, FARSHID AMIR ABBAS. THE ULTRASTRUCTURAL STUDY OF OOCYTE AND ZONA PELLUCIDA IN OVARIAN FOLLICLES OF UNTREATED AND AND METFORMIN-TREATED DIABETIC RATS SUBSEQUENT TO INDUCTION OF EXPERIMENTAL DIABETES. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2011;69(6):366-373. Available from: https://sid.ir/paper/39427/en

IEEE: Copy

POUYA POURNAGHI, RAJAB ALI SADRKHANLOO, SHAPOUR HASANZADEH, and AMIR ABBAS FARSHID, “THE ULTRASTRUCTURAL STUDY OF OOCYTE AND ZONA PELLUCIDA IN OVARIAN FOLLICLES OF UNTREATED AND AND METFORMIN-TREATED DIABETIC RATS SUBSEQUENT TO INDUCTION OF EXPERIMENTAL DIABETES,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 69, no. 6, pp. 366–373, 2011, [Online]. Available: https://sid.ir/paper/39427/en

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