Effect of Metformin on Some Cognitive Functions in Old Rats

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Pak Hashemi Mohammad; HASSANIPOUR MAHSA; KAEIDI AYAT; Saeed Askari Pooya; FATEMI IMAN; RAHMANI MOHAMMAD REZA; HAKIMIZADEH ELHAM; HASSANSHAHI JALAL; EHSANI VAHID; TAGHIPOUR ZAHRA; KHADEMI MARZIEH; ALLAHTAVAKOLI MOHAMMAD

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2020 | Volume:28 | Issue:3 Page(s): 2479-2489

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Title

Effect of Metformin on Some Cognitive Functions in Old Rats

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Keywords

AgingQ2

MetforminQ2

DepressionQ2

AnxietyQ2

RatQ2

Abstract

Introduction: Aging is a complex process and is considered as a risk factor for many diseases such as hypertension, Alzheimer, cancer, Depression and Anxiety. Recently, it has been shown that Metformin, an anti-diabetic drug, has important neurological effects such as preventing memory loss, stroke, Anxiety, inflammation and seizures. Therefore, the aim of this study was investigating the effects of Metformin on some cognitive factors in elderly male Rats. Methods: 24 Rats (22 months) were randomly divided into 3 groups (n=8). The first group was the control group that received water orally, the second group received Metformin 1 mg/kg orally and the third group received Metformin 10 mg/kg orally. After treatment for 40 days (once daily), behavioral tests, including Ymaze, elevated plus maze and Depression test were performed on animals. Results were analyzed using GraphPad Prism version 6 and One-way ANOVA followed by Tukey-post hoc test. Results: The results of this study showed that Metformin at a dose of 10 mg/kg significantly reduced Anxiety (P<0. 001) and Depression (P<0. 001) in older animals. Metformin at a dose of 1 mg/kg failed to improve Agingrelated disorders in this model. Conclusion: Metformin at a dose of 10 mg/kg can reduce the quality of life by reducing Anxiety and Depression.

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APA: Copy

Pak Hashemi, Mohammad, HASSANIPOUR, MAHSA, KAEIDI, AYAT, Saeed Askari, Pooya, FATEMI, IMAN, RAHMANI, MOHAMMAD REZA, HAKIMIZADEH, ELHAM, HASSANSHAHI, JALAL, EHSANI, VAHID, TAGHIPOUR, ZAHRA, KHADEMI, MARZIEH, & ALLAHTAVAKOLI, MOHAMMAD. (2020). Effect of Metformin on Some Cognitive Functions in Old Rats. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 28(3 ), 2479-2489. SID. https://sid.ir/paper/398424/en

Vancouver: Copy

Pak Hashemi Mohammad, HASSANIPOUR MAHSA, KAEIDI AYAT, Saeed Askari Pooya, FATEMI IMAN, RAHMANI MOHAMMAD REZA, HAKIMIZADEH ELHAM, HASSANSHAHI JALAL, EHSANI VAHID, TAGHIPOUR ZAHRA, KHADEMI MARZIEH, ALLAHTAVAKOLI MOHAMMAD. Effect of Metformin on Some Cognitive Functions in Old Rats. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;28(3 ):2479-2489. Available from: https://sid.ir/paper/398424/en

IEEE: Copy

Mohammad Pak Hashemi, MAHSA HASSANIPOUR, AYAT KAEIDI, Pooya Saeed Askari, IMAN FATEMI, MOHAMMAD REZA RAHMANI, ELHAM HAKIMIZADEH, JALAL HASSANSHAHI, VAHID EHSANI, ZAHRA TAGHIPOUR, MARZIEH KHADEMI, and MOHAMMAD ALLAHTAVAKOLI, “Effect of Metformin on Some Cognitive Functions in Old Rats,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 3 , pp. 2479–2489, 2020, [Online]. Available: https://sid.ir/paper/398424/en

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