CELECOXIB - CHEMORADIATION THERAPY FOR REDUCING MUCOSITIS AND OTHER ACUTE SIDE EFFECTS IN ADVANCE HEAD AND NECK CARCINOMA

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MOJAHED M.M.; AGHILI M.; KAZEMIAN ALI; FARHAN F.; IZADI SHAHRZAD

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Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2009 | Volume:66 | Issue:11 Page(s): 797-803

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Title

CELECOXIB - CHEMORADIATION THERAPY FOR REDUCING MUCOSITIS AND OTHER ACUTE SIDE EFFECTS IN ADVANCE HEAD AND NECK CARCINOMA

Author(s)

Keywords

HEAD AND NECK CANCERQ3

CHEMORADIATIONQ3

ACUTE TOXICITIESQ3

MUCOSITISQ3

COX-2Q3

CELECOXIBQ3

Abstract

Background: Chemo-radiotherapy-induced oral MUCOSITIS represents a therapeutic challenge frequently encountered in cancer patients. This side effect causes significant morbidity and may delay or interruption of treatment plan, cyclo-oxygenase 2 (COX2) is an inducible enzyme primarily expressed in inflamed and tumoral tissues. COX-2 inhibitors have shown promise to reduce CHEMORADIATION induce toxicities. We conducted a phase III, randomized double blind clinical trial to evaluate the toxicity and efficacy of CELECOXIB, a selective COX2 inhibitor, administered concurrently with CHEMORADIATION for locally advanced HEAD AND NECK CANCER. Here in we report the first report about the role of COX-2 inhibitor in acute toxicicities.Methods: Patients with stage III/IV (locally advance) head and neck carcinoma who referred to department of radiation-oncology were eligible. Patients were treated with chemotherapy with cisplatin concurrently with radiation (60-70Gy). CELECOXIB (100mg qid) was started at the first day of radiotherapy and was given for a total of 8 weeks.Acute toxicities were evaluated every week by WHO scale.Results: One hundred twenty two patients were enrolled into the study, (61 patients for each group). In repeated mesurment analysis of variance there is a significant difference in the time of onset of grade II ACUTE TOXICITIES between the two groups; The MUCOSITIS, dysphagia, epidermitis and oral pain score changed significantly over the typical five weeks in two groups but these changes were more sever in placebo group (p=0.0001). In the analysis of the overall changes in the following laboratory parameters: WBC, hemoglobin and platelet showed that these parameters decreased over time in both groups without a significant difference between groups.Conclusion: The results of these study showed that the use of a COX-2 inhibitor (celecoxib) that is a safe and inexpensive drug may reduce ACUTE TOXICITIES of CHEMORADIATION specially MUCOSITIS in head and neck carcinoma.

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APA: Copy

MOJAHED, M.M., AGHILI, M., KAZEMIAN, ALI, FARHAN, F., & IZADI, SHAHRZAD. (2009). CELECOXIB - CHEMORADIATION THERAPY FOR REDUCING MUCOSITIS AND OTHER ACUTE SIDE EFFECTS IN ADVANCE HEAD AND NECK CARCINOMA. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 66(11), 797-803. SID. https://sid.ir/paper/39457/en

Vancouver: Copy

MOJAHED M.M., AGHILI M., KAZEMIAN ALI, FARHAN F., IZADI SHAHRZAD. CELECOXIB - CHEMORADIATION THERAPY FOR REDUCING MUCOSITIS AND OTHER ACUTE SIDE EFFECTS IN ADVANCE HEAD AND NECK CARCINOMA. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2009;66(11):797-803. Available from: https://sid.ir/paper/39457/en

IEEE: Copy

M.M. MOJAHED, M. AGHILI, ALI KAZEMIAN, F. FARHAN, and SHAHRZAD IZADI, “CELECOXIB - CHEMORADIATION THERAPY FOR REDUCING MUCOSITIS AND OTHER ACUTE SIDE EFFECTS IN ADVANCE HEAD AND NECK CARCINOMA,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 66, no. 11, pp. 797–803, 2009, [Online]. Available: https://sid.ir/paper/39457/en

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