LEVEL, OF CYTOKINES (LIKE IL-1Β , IL-6 , IL-8 AND TNF-Α) IN PLATELET CONCENTRATES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHAIGAN MOZHGAN; POURFATH A.A.; NOMEIRI M.; BABAEI G.R.; TARABADI F.A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download Full-Text

Persian Verion

View:

804

Download:

Cites:

Information Journal Paper

Title

LEVEL, OF CYTOKINES (LIKE IL-1Β , IL-6 , IL-8 AND TNF-Α) IN PLATELET CONCENTRATES

Author(s)

Keywords

PLATELET CONCENTRATESQ4

FNHTRQ4

IL-ΒQ4

IL-6Q4

IL-8Q4

TNF- ΑQ4

ELISAQ4

Abstract

Background: As increase of cytokines (like IL-1b , IL-6 , IL-8 and TNF- a) in PLATELET CONCENTRATES (PCs) during storage are involved in Febrile Non Hemolytic Transfusion Reactions (FNHTRs) after Platelet transfusion, the aim of this study was the survey of these cytokines level in PCs produced in Tehran Blood Center.Materials and Methods: This study proposed to determine if WBC reduction in PCs by pre-storage leuckodepletion filters reduced the levels of these cytokines during storage uo 3 days. Each of the PCs (n=54) was prepared from single random donor (RD) by Platelet-Rich-Plasma (pRP), then were divided in four groups: 1- unfiltered non-irradiated RD-PCs (n= 13) 2- unfiltered and y-irradiated RD-PCs (n=16) 3 - filtered non-irradiated RD-PCs (n=14) 4-filtered and y-irradiated RD-PCs (n=11). Cytokines levels in PCs supernatants were measured by EUSA kits according manufactures instructions.Results: Our results showed: IL-8 was increased in unfiltered non-irradiated and IL-18 in g-irradiated RD-PCs but not in the filtered RD-PCs in day 3 . Compared to unfiltered PCs in filtered units. pre-storage filtration prevented a rise in the IL-8 and TNF- a in day 3 of storage. The concentration of IL-1b was lower than the minimal detectable concentration by the kits used for this purpose. IL-6 was detected only in 7 units of all filtered PCs in day 3. Conclusion: These data indicate that pre-storage leuko-reduction of PCs can prevent accumulation of IL-6, IL-8 and TNF-a during storage.

Cites

No record.

References

No record.

Cite

APA: Copy

SHAIGAN, MOZHGAN, POURFATH, A.A., NOMEIRI, M., BABAEI, G.R., & TARABADI, F.A.. (2004). LEVEL, OF CYTOKINES (LIKE IL-1Β , IL-6 , IL-8 AND TNF-Α) IN PLATELET CONCENTRATES. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 62(4), 302-309. SID. https://sid.ir/paper/39485/en

Vancouver: Copy

SHAIGAN MOZHGAN, POURFATH A.A., NOMEIRI M., BABAEI G.R., TARABADI F.A.. LEVEL, OF CYTOKINES (LIKE IL-1Β , IL-6 , IL-8 AND TNF-Α) IN PLATELET CONCENTRATES. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2004;62(4):302-309. Available from: https://sid.ir/paper/39485/en

IEEE: Copy

MOZHGAN SHAIGAN, A.A. POURFATH, M. NOMEIRI, G.R. BABAEI, and F.A. TARABADI, “LEVEL, OF CYTOKINES (LIKE IL-1Β , IL-6 , IL-8 AND TNF-Α) IN PLATELET CONCENTRATES,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 62, no. 4, pp. 302–309, 2004, [Online]. Available: https://sid.ir/paper/39485/en

Related Journal Papers