THE STUDY OF TH1/TH2 CYTOKINE PROFILES (IL-10, IL-12, IL-4, AND IFNΓ) IN PBMCS OF PATIENTS WITH MULTIDRUG RESISTANT TUBERCULOSIS AND NEWLY DIAGNOSED DRUG RESPONSIVE CASES

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SHEKARABI M.; MIANDEHI N.; MANSOURI S.D.; TAVASOLI FAYRI M.; ALIBAHAR M.; AMIRKHANI A.; MIRSAEIDI SEYED MAHDI

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Journal: TANAFFOS Year:2004 | Volume:3 | Issue:10 Page(s): 25-31

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Title

THE STUDY OF TH1/TH2 CYTOKINE PROFILES (IL-10, IL-12, IL-4, AND IFNΓ) IN PBMCS OF PATIENTS WITH MULTIDRUG RESISTANT TUBERCULOSIS AND NEWLY DIAGNOSED DRUG RESPONSIVE CASES

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Keywords

TH1/TH2 CYTOKINE PROFILESQ4

TUBERCULOSISQ4

MDR-TBQ4

Abstract

Background: Multi-drug resistant TUBERCULOSIS (MDR-TB), which is a worldwide clinical problem, is associated with high morbidity and mortality, as well as long-term survival of infected immunocompetent patients. In this study, the PPD-induced production of IL-12, IL-10, IFNg, and IL-4 in peripheral blood mononuclear cells (PBMC) from patients with MDR-TB were investigated and compared with cytokine production capabilities in newly diagnosed, treated cases.Materials and Methods: This study investigated the profiles of IFN-g, IL-12, IL-10, and IL-4 in response to a purified protein derivative (PPD) in peripheral blood mononuclear cells (PBMC) from 15 HIV negative patients with multidrug-resistant TUBERCULOSIS (MDR-TB), 11 newly diagnosed, treated cases and compared those with 10 healthy negative tuberculin reactors as controls.Results: ELISA results showed that the following stimulation with PPD, IFNg production was significantly increased, whereas IL-10 was significantly reduced in MDR-TB patients compared with PPD negative controls. Production of IL-12 in MDR-TB patients showed elevation, induced by PPD stimulation of their PBMCs. However, MDR-TB patients were similar to healthy negative tuberculin controls in their IL-12 production and there was no statistically significant difference between them. IL-4 was detected to be in very low levels in three groups.Conclusion: In this study MDR-TB patients have no dysregulation in IL-12 or IL-10 production during Mycobacterium TUBERCULOSIS infection, and profiles are prone to Th1 cytokines.

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APA: Copy

SHEKARABI, M., MIANDEHI, N., MANSOURI, S.D., TAVASOLI FAYRI, M., ALIBAHAR, M., AMIRKHANI, A., & MIRSAEIDI, SEYED MAHDI. (2004). THE STUDY OF TH1/TH2 CYTOKINE PROFILES (IL-10, IL-12, IL-4, AND IFNΓ) IN PBMCS OF PATIENTS WITH MULTIDRUG RESISTANT TUBERCULOSIS AND NEWLY DIAGNOSED DRUG RESPONSIVE CASES. TANAFFOS, 3(10), 25-31. SID. https://sid.ir/paper/52729/en

Vancouver: Copy

SHEKARABI M., MIANDEHI N., MANSOURI S.D., TAVASOLI FAYRI M., ALIBAHAR M., AMIRKHANI A., MIRSAEIDI SEYED MAHDI. THE STUDY OF TH1/TH2 CYTOKINE PROFILES (IL-10, IL-12, IL-4, AND IFNΓ) IN PBMCS OF PATIENTS WITH MULTIDRUG RESISTANT TUBERCULOSIS AND NEWLY DIAGNOSED DRUG RESPONSIVE CASES. TANAFFOS[Internet]. 2004;3(10):25-31. Available from: https://sid.ir/paper/52729/en

IEEE: Copy

M. SHEKARABI, N. MIANDEHI, S.D. MANSOURI, M. TAVASOLI FAYRI, M. ALIBAHAR, A. AMIRKHANI, and SEYED MAHDI MIRSAEIDI, “THE STUDY OF TH1/TH2 CYTOKINE PROFILES (IL-10, IL-12, IL-4, AND IFNΓ) IN PBMCS OF PATIENTS WITH MULTIDRUG RESISTANT TUBERCULOSIS AND NEWLY DIAGNOSED DRUG RESPONSIVE CASES,” TANAFFOS, vol. 3, no. 10, pp. 25–31, 2004, [Online]. Available: https://sid.ir/paper/52729/en

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