THE RELATIONSHIP OF EXTRACELLULAR- SUPEROXIDE DISMUTASE ENZYME (EC-SOD) WITH OXIDIZED- LOW DENSITY LIPOPROTEIN IN TYPE 2 DIABETES WITH MACRO AND NORMOALBUMINURIA

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ASGARANI F.; KHAJEHALI L.; ESFAHANIAN F.; VOSOUGH M.H.; ESTEGHAMATI A.R.; NAKHJAVANI MANOUCHEHR

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Tehran University Medical Journal Year:2009 | Volume:67 | Issue:9 Page(s): 608-614

Download Full-Text

Persian Verion

View:

779

Download:

Cites:

Information Journal Paper

Title

THE RELATIONSHIP OF EXTRACELLULAR- SUPEROXIDE DISMUTASE ENZYME (EC-SOD) WITH OXIDIZED- LOW DENSITY LIPOPROTEIN IN TYPE 2 DIABETES WITH MACRO AND NORMOALBUMINURIA

Author(s)

Keywords

DIABETES MELLITUSQ1

OXIDIZED- LDLQ3

EXTRACELLULAR-SODQ3

PROTEINURIAQ3

Abstract

Background: Increased rate of oxidative stress have important role in diabetic nephropathy. Oxidative stress induces the synthesis of antioxidant enzymes. One of them, Extracellular- SOD (EC–SOD) is a major anti-oxidative enzyme and the only one that neutralizes superoxide ion, a precursor of reactive oxygen species (ROS). The aim of this study was to evaluate the correlation between diabetes- associated oxidative stress and antioxidative defense in macroalbuminuric type II diabetic patients.Methods: One hundred and thirty three patients (74 women, 59 men) with type II diabetes were studied during 1385-86. According to level of urinary protein, two groups of patients; normoalbuminuric (urinary protein excertion below 30mg/24h) and macroalbuminuric (urinary protein excretion more than 300mg/24) were recognized. In each group serum level of OXIDIZED- LDL and EC-SOD were measured.Results: The mean age of patients and the mean duration of diabetes was 59.09±8.26 years and 137.92±65.91 months, respectively. The plasma oxidized-LDL level and extracellular- superoxide dimutase level were significantly higher in macroalbuminuric than normoalbuminuric group (88.57±33.36 versus 78.24±27.59u/l, p=0.039 for oxidized-LDL and 87.60±21.18 versus 76.25±16.25mu/l, p<0.001 for EC-SOD). OXIDIZED- LDL was significantly correlated to EC-SOD in macroalbuminuric patients (r=0.425, p<0.0001).Oxidized-LDL and EC-SOD does not correlate to Fasting Plasma Glucose and HbA1c in each two groups.Conclusion: The significantly elevated plasma oxidized-LDL in patients with macroalbuminuria suggests that, oxidized-LDL may play an important role in the progression of diabetic nephropathy. Besides severity of oxidative stress in macroalbuminuic patients, increase level of EC-SOD enzyme could be a compensatory mechanism to prevent tissue damage.

Cites

No record.

References

No record.

Cite

APA: Copy

ASGARANI, F., KHAJEHALI, L., ESFAHANIAN, F., VOSOUGH, M.H., ESTEGHAMATI, A.R., & NAKHJAVANI, MANOUCHEHR. (2009). THE RELATIONSHIP OF EXTRACELLULAR- SUPEROXIDE DISMUTASE ENZYME (EC-SOD) WITH OXIDIZED- LOW DENSITY LIPOPROTEIN IN TYPE 2 DIABETES WITH MACRO AND NORMOALBUMINURIA. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 67(9), 608-614. SID. https://sid.ir/paper/39492/en

Vancouver: Copy

ASGARANI F., KHAJEHALI L., ESFAHANIAN F., VOSOUGH M.H., ESTEGHAMATI A.R., NAKHJAVANI MANOUCHEHR. THE RELATIONSHIP OF EXTRACELLULAR- SUPEROXIDE DISMUTASE ENZYME (EC-SOD) WITH OXIDIZED- LOW DENSITY LIPOPROTEIN IN TYPE 2 DIABETES WITH MACRO AND NORMOALBUMINURIA. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2009;67(9):608-614. Available from: https://sid.ir/paper/39492/en

IEEE: Copy

F. ASGARANI, L. KHAJEHALI, F. ESFAHANIAN, M.H. VOSOUGH, A.R. ESTEGHAMATI, and MANOUCHEHR NAKHJAVANI, “THE RELATIONSHIP OF EXTRACELLULAR- SUPEROXIDE DISMUTASE ENZYME (EC-SOD) WITH OXIDIZED- LOW DENSITY LIPOPROTEIN IN TYPE 2 DIABETES WITH MACRO AND NORMOALBUMINURIA,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 67, no. 9, pp. 608–614, 2009, [Online]. Available: https://sid.ir/paper/39492/en

Related Journal Papers