Evaluation of the alcoholic extract effect of Artemisia fragranceherbal with chloroquineon Plasmodium berghei in laboratory albino mice

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NAJM MEHDI; Heidari Aliehsan; Hadighi Ramtine; Bahadori Saeed; KABIR KOUROSH; NAGHAVI MOHAMMAD REZA; SEZAVAR MONIREH

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Journal: Razi Journal of Medical Sciences Year:2019 | Volume:26 | Issue:2 Page(s): 65-73

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Title

Evaluation of the alcoholic extract effect of Artemisia fragranceherbal with chloroquineon Plasmodium berghei in laboratory albino mice

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Keywords

Artemisia fragranceQ1

ChloroquineQ3

Plasmodium bergheiQ1

Antimalarial effectsQ1

Laboratory albino miceQ2

Abstract

Background: Malaria is one of the most important tropical diseases that is prevalent in some of regions of Iran and world. The malaria agent is resistant to different chemical drugs which have several side effects. So the use of various medicinal plants, especially different species ofArtemisiaherb which have artemisinin as its active ingredient, is significantly important. Therefore, the aim of this study was to evaluate the effect of alcoholic extract of Artemisia fragrance herb as compared withChloroquine in Laboratory albino mice exposed to Plasmodium berghei (P. berghei). Methods: In this experimental study, twenty-five mice were divided into five groups (n=25 mice/group) placed in separate cages: four groups were infected with P. berghei, Two groups were treated with different concentrations (25 and 75 mg/kg) of alcoholic extract of Artemisia fragrance and one group was treated with Chloroquine current drug. The fourth group was assigned as a placebo group without receiving any drugs. The data were analysed using SPSS software and Paired and student T-test. Results: In groups treated with 25 and 75 mg of the extract, parasitemia decreased significantly on days 5 and 8 compared to placebo groups (p<0. 001). Mean while, the parasitemia rate decreased in the 75 mg group than in the group receiving 25 mg on day 5 (p<0. 005). The life span of the mice in the group treated with Chloroquine and 75 mg of the extract had a statistically significant difference with other groups (p<0. 05). Conclusion: This study showed that alcoholic extract of Artemisia fragrance in 75 mg/kg mice weight concentration has a significant effect on P. berghei parasite.

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References

Pharmacochemistry of Iranian flora Artemisia oliveriana and its anti malarial effects on Plasmodium berghei in vivo

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APA: Copy

NAJM, MEHDI, Heidari, Aliehsan, Hadighi, Ramtine, Bahadori, Saeed, KABIR, KOUROSH, NAGHAVI, MOHAMMAD REZA, & SEZAVAR, MONIREH. (2019). Evaluation of the alcoholic extract effect of Artemisia fragranceherbal with chloroquineon Plasmodium berghei in laboratory albino mice. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 26(2 ), 65-73. SID. https://sid.ir/paper/395049/en

Vancouver: Copy

NAJM MEHDI, Heidari Aliehsan, Hadighi Ramtine, Bahadori Saeed, KABIR KOUROSH, NAGHAVI MOHAMMAD REZA, SEZAVAR MONIREH. Evaluation of the alcoholic extract effect of Artemisia fragranceherbal with chloroquineon Plasmodium berghei in laboratory albino mice. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2019;26(2 ):65-73. Available from: https://sid.ir/paper/395049/en

IEEE: Copy

MEHDI NAJM, Aliehsan Heidari, Ramtine Hadighi, Saeed Bahadori, KOUROSH KABIR, MOHAMMAD REZA NAGHAVI, and MONIREH SEZAVAR, “Evaluation of the alcoholic extract effect of Artemisia fragranceherbal with chloroquineon Plasmodium berghei in laboratory albino mice,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 26, no. 2 , pp. 65–73, 2019, [Online]. Available: https://sid.ir/paper/395049/en

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