ASSESSMENT OF IN VITRO ACTIVITY OF PEGANUM HARMALA EXTRACT ON PLASMODIUM FALCIPARUM GROWTH COMPARED WITH CHLOROQILLNE

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SHARBATKHOURI M.; NATEGHPOUR M.; EDRISIAN GH.H.; SOORI E.; MOHEBALI M.; AKBARZADEH K.; MOTEVALI HAGHI A.; SATVAT M.T.; RAHIMI A.

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Journal: Studies in Medical Sciences Year:2006 | Volume:17 | Issue:2 Page(s): 101-108

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Title

ASSESSMENT OF IN VITRO ACTIVITY OF PEGANUM HARMALA EXTRACT ON PLASMODIUM FALCIPARUM GROWTH COMPARED WITH CHLOROQILLNE

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Keywords

PEGANUM HARMALAQ3

PLASMODIUM FALCIPARUMQ4

CHLOROQUINEQ3

Abstract

Background & Aims: Malaria is one of the most important parasitic diseases in the world. More than forty percent of the world population lives in malarious regions. With the emergence of CHLOROQUINE resistant strains of PLASMODIUM FALCIPARUM in recent decades, the malarious countries faced some difficulties in treating acute cases of the diseases. Because of this, the need for finding some new drugs with minimal side effects is essential. A few plants have been used for several thousand years as the traditional antimalarial remedies in different parts of the world such as Iran.Materials & Methods: PEGANUM HARMALA extract was evaluated in four serial dilutions including 12.5, 25,50 and 100 mg/ml and CHLOROQUINE with 8 picomol/well using in vitro method on 23 blood samples from patients infected by plasmodium fa1ciparum.Result: All four serial dilutions of PEGANUM HARMALA extract could inhibit parasite growth (P<0.05). In comparison with CHLOROQUINE at doses of 12.5 mg/ml and 25 mg/ml, it was less effective than CHLOROQUINE while 50 mg/ml and 100 mg/ml had almost similar results to CHLOROQUINE. PEGANUM HARMALA in doses of 50 and 100 mg/ml could significantly decrease schizont formation of those two strains of plasmodium fa1ciparumparasites which were resistant to CHLOROQUINE.

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APA: Copy

SHARBATKHOURI, M., NATEGHPOUR, M., EDRISIAN, GH.H., SOORI, E., MOHEBALI, M., AKBARZADEH, K., MOTEVALI HAGHI, A., SATVAT, M.T., & RAHIMI, A.. (2006). ASSESSMENT OF IN VITRO ACTIVITY OF PEGANUM HARMALA EXTRACT ON PLASMODIUM FALCIPARUM GROWTH COMPARED WITH CHLOROQILLNE. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 17(2), 101-108. SID. https://sid.ir/paper/64296/en

Vancouver: Copy

SHARBATKHOURI M., NATEGHPOUR M., EDRISIAN GH.H., SOORI E., MOHEBALI M., AKBARZADEH K., MOTEVALI HAGHI A., SATVAT M.T., RAHIMI A.. ASSESSMENT OF IN VITRO ACTIVITY OF PEGANUM HARMALA EXTRACT ON PLASMODIUM FALCIPARUM GROWTH COMPARED WITH CHLOROQILLNE. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2006;17(2):101-108. Available from: https://sid.ir/paper/64296/en

IEEE: Copy

M. SHARBATKHOURI, M. NATEGHPOUR, GH.H. EDRISIAN, E. SOORI, M. MOHEBALI, K. AKBARZADEH, A. MOTEVALI HAGHI, M.T. SATVAT, and A. RAHIMI, “ASSESSMENT OF IN VITRO ACTIVITY OF PEGANUM HARMALA EXTRACT ON PLASMODIUM FALCIPARUM GROWTH COMPARED WITH CHLOROQILLNE,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 17, no. 2, pp. 101–108, 2006, [Online]. Available: https://sid.ir/paper/64296/en

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