Comparing the Effect of Ethanol Amine, Povidone-iodine and Talcum Powder on Induction of Pleurodesis in Rats

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LASHKARIZADEH MOHAMMAD REZA; Pourdavood Amirhossein; Salehi Amir Reza; AMIRBEIGI ALIREZA

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2019 | Volume:29 | Issue:178 Page(s): 107-114

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Title

Comparing the Effect of Ethanol Amine, Povidone-iodine and Talcum Powder on Induction of Pleurodesis in Rats

Author(s)

LASHKARIZADEH MOHAMMAD REZA | Pourdavood Amirhossein | Salehi Amir Reza | AMIRBEIGI ALIREZA | Issue Writer Certificate

Keywords

pleurodesisQ1

fibrosisQ2

ratsQ2

ethanolamineQ1

Povidone-iodineQ1

talcum powderQ3

Abstract

Background and purpose: Malignant pleural effusion have significant impacts on patients live. This study was designed to determine the effect of Ethanolamine, Povidone-iodine, and talcum powder on pleurodesis in rats. Materials and methods: This experimental study was conducted in 36 adult male rats in Neuroscience Research Center affiliated to Kerman University of Medical Sciences, Iran 2018. The rats were randomly divided into four groups: Ethanolamine, Povidone-iodine, talcum Powder, and Salin (control group). The sclerosing agent was injected in each group. Then, microscopic and macroscopic effects of the drugs were compared. Data were analyzed applying Fisher’ s exact test and multivariate analysis in SPSS. Results: The most severe fibrosis was seen in groups that had received Ethanolamine (85. 6% severe fibrosis), while the group that received Povidone-iodine and talcum powder showed moderate fibrosis (61. 5% and 38. 5%, respectively). The rate of fibrosis was significantly higher in control group (72. 7% mild fibrosis, P<0. 001). Compared with the control group, more chronic inflammation was seen in the group that received Ethanolamine (P=0. 004). Conclusion: According to this study Ethanolamine and Povidone-iodine could be used as effective agents for inducing pleurodesis. Their low cost and availability make them good alternatives to other materials.

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APA: Copy

LASHKARIZADEH, MOHAMMAD REZA, Pourdavood, Amirhossein, Salehi, Amir Reza, & AMIRBEIGI, ALIREZA. (2019). Comparing the Effect of Ethanol Amine, Povidone-iodine and Talcum Powder on Induction of Pleurodesis in Rats. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 29(178 ), 107-114. SID. https://sid.ir/paper/395431/en

Vancouver: Copy

LASHKARIZADEH MOHAMMAD REZA, Pourdavood Amirhossein, Salehi Amir Reza, AMIRBEIGI ALIREZA. Comparing the Effect of Ethanol Amine, Povidone-iodine and Talcum Powder on Induction of Pleurodesis in Rats. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;29(178 ):107-114. Available from: https://sid.ir/paper/395431/en

IEEE: Copy

MOHAMMAD REZA LASHKARIZADEH, Amirhossein Pourdavood, Amir Reza Salehi, and ALIREZA AMIRBEIGI, “Comparing the Effect of Ethanol Amine, Povidone-iodine and Talcum Powder on Induction of Pleurodesis in Rats,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 29, no. 178 , pp. 107–114, 2019, [Online]. Available: https://sid.ir/paper/395431/en

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