Kinetoplast DNA: A Promising Drug Target for Treatment of Leishmaniasis

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KIALASHAKI ELHAM; FAKHAR MAHDI; AKHTARI JAVAD; FARIDNIA ROGHIYEH; KEIGHOBADI MASOUD

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2020 | Volume:30 | Issue:184 Page(s): 179-193

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Title

Kinetoplast DNA: A Promising Drug Target for Treatment of Leishmaniasis

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Keywords

LeishmaniaQ2

kinetoplastQ1

DNA topoisomeraseQ1

drug targetQ1

Abstract

Leishmaniasis is a vector-borne zoonotic disease caused by various species of the genus Leishmania, (trypanosomatidae family) that is transmitted by phlebotomine sandflies. The disease can present in a range of clinical forms, including dermal lesions, metastasis mucocutaneous forms, and fatal visceral forms. In this non-systematic review, we aimed at introducing the role of kinetoplast DNA (kDNA) and dependent topoisomerases (TPI) as potential chemotherapeutic targets for treatment of Leishmaniasis. The Leishmania parasite has a mitochondrial DNA located in the attached circles. KDNA replication process is very complex and a large number of proteins are involved. Some of them are classified as topoisomerases, which play major biological roles in the effective cell processes in the topology, synthesis, and organization of kDNA and constitute the main drug target in kinetoplast for Leishmaniasis cure. Several studies have shown that the inhibitors of TPI exchange these enzymes into intracellular cell toxins and provide an appropriate tool for killing the parasite in the host. DNA binding drugs have also been reported as therapeutic agents against Leishmanial infections.

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APA: Copy

KIALASHAKI, ELHAM, FAKHAR, MAHDI, AKHTARI, JAVAD, FARIDNIA, ROGHIYEH, & KEIGHOBADI, MASOUD. (2020). Kinetoplast DNA: A Promising Drug Target for Treatment of Leishmaniasis. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 30(184 ), 179-193. SID. https://sid.ir/paper/397491/en

Vancouver: Copy

KIALASHAKI ELHAM, FAKHAR MAHDI, AKHTARI JAVAD, FARIDNIA ROGHIYEH, KEIGHOBADI MASOUD. Kinetoplast DNA: A Promising Drug Target for Treatment of Leishmaniasis. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;30(184 ):179-193. Available from: https://sid.ir/paper/397491/en

IEEE: Copy

ELHAM KIALASHAKI, MAHDI FAKHAR, JAVAD AKHTARI, ROGHIYEH FARIDNIA, and MASOUD KEIGHOBADI, “Kinetoplast DNA: A Promising Drug Target for Treatment of Leishmaniasis,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 30, no. 184 , pp. 179–193, 2020, [Online]. Available: https://sid.ir/paper/397491/en

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