Comparison of the Effect of High Intensity Interval Training and Moderate Intensity Continuous Training on Gene Expression of Il-6 and Nf-Kb in Lung Tissue of Old and Young Male Rats

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Motieihaghighi M.; SOORI R.; SHABKHIZ F.; CHOOBINEH S.

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Journal: Journal of Ilam University of Medical Sciences Year:2020 | Volume:27 | Issue:5 Page(s): 54-64

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Title

Comparison of the Effect of High Intensity Interval Training and Moderate Intensity Continuous Training on Gene Expression of Il-6 and Nf-Kb in Lung Tissue of Old and Young Male Rats

Author(s)

Motieihaghighi M. | SOORI R. | SHABKHIZ F. | CHOOBINEH S. | Issue Writer Certificate

Keywords

AgingQ1

Exercise trainingQ1

InflammationQ1

Interleukin-6Q1

Abstract

Introduction: Aging is accompanied by an increase in Inflammation in the tissues of the body, which also causes lung Inflammation. This study aimed to compare the effect of high-intensity interval training and moderate-intensity continuous training on gene expression of NF-κ B and IL-6 in lung tissue of old and young male rats. Materials & Methods: In total, 42 young and old male Wistar rats were randomly divided into 6 groups, namely young control, old control, young continuous training, old continuous training, young high-intensity interval training, and old high-intensity interval training. The training protocol included high-intensity interval training and moderate-intensity continuous training during six-week (5 sessions per week). The gene expression of NF-κ B and IL-6 were evaluated using a real-time polymerase chain reaction technique, and the data were analyzed through a one-way analysis of variance and the Scheffe post hoc test (P<0. 05). Ethics code: IR. ut. Rec. 1395005 Findings: There were significant differences between old control and old continuous training (P<0. 001), old control and old high-intensity interval training (P<0. 001), as well as old continuous training and old high-intensity interval training groups (P=0. 007) regarding the gene expression of NF-κ B. Moreover, significant differences were observed between old control and old continuous training (P<0. 001), as well as old control and old high-intensity interval training groups (P=0. 006) in terms of the gene expression of IL-6. In addition, there was a significant difference between young highintensity interval training and old highintensity interval training groups (P=0. 035) regarding the gene expression of IL-6. Discussion & Conclusions: According to the results, both high-intensity interval training and moderate-intensity continuous training can result in the prevention of the incidence of Aging-related diseases and disorders as well as the reduction of inflammatory factors in lung tissue in aged rats. However, it seems that moderateintensity continuous training is more effective than high-intensity interval training.

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APA: Copy

Motieihaghighi, M., SOORI, R., SHABKHIZ, F., & CHOOBINEH, S.. (2020). Comparison of the Effect of High Intensity Interval Training and Moderate Intensity Continuous Training on Gene Expression of Il-6 and Nf-Kb in Lung Tissue of Old and Young Male Rats. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 27(5 ), 54-64. SID. https://sid.ir/paper/398036/en

Vancouver: Copy

Motieihaghighi M., SOORI R., SHABKHIZ F., CHOOBINEH S.. Comparison of the Effect of High Intensity Interval Training and Moderate Intensity Continuous Training on Gene Expression of Il-6 and Nf-Kb in Lung Tissue of Old and Young Male Rats. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;27(5 ):54-64. Available from: https://sid.ir/paper/398036/en

IEEE: Copy

M. Motieihaghighi, R. SOORI, F. SHABKHIZ, and S. CHOOBINEH, “Comparison of the Effect of High Intensity Interval Training and Moderate Intensity Continuous Training on Gene Expression of Il-6 and Nf-Kb in Lung Tissue of Old and Young Male Rats,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 5 , pp. 54–64, 2020, [Online]. Available: https://sid.ir/paper/398036/en

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