Effect of high intensity interval and continuous endurance training on TRF2 and TERT gene expression in heart tissue of aging male rats

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ESKANDARI AREZOO; Fashi Mohamad; DAKHILI AMIRBAHADOR

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Paper Information

Journal: JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES Year:2019 | Volume:21 | Issue:2 (70) Page(s): 43-49

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Information Journal Paper

Title

Effect of high intensity interval and continuous endurance training on TRF2 and TERT gene expression in heart tissue of aging male rats

Author(s)

ESKANDARI AREZOO | Fashi Mohamad | DAKHILI AMIRBAHADOR | Issue Writer Certificate

Keywords

High intensity interval trainingQ1

Continuous endurance trainingQ1

TRF2 geneQ1

TERT geneQ1

AgingQ2

RatsQ2

Abstract

Background and Objective: Age is the greatest risk factor for cardiovascular disease that is associated with shortens telomere. TRF2 and TERT genes expression in heart tissue reduce in elderly. These geness are associated with shortens telomere. Exercise can play a useful role in maintaining the length of telomeres. This study was carry out to determine the effect of High intensity interval training (HIIT) and Continuous endurance training on TRF2 and TERT gene expression in heart tissue of aged male Rats. Methods: In this experimental study 24 adult aged male Rats (88-96 weeks, 363± 12 g) allocated into three groups including control, endurance training (5 sessions per week: with 60-70 of maximum speed of group) and HIIT (5 sessions per week: 80 percent in the first and second week, 90% maximum speed of the third week, 100 % until the end of the exercise for 6 weeks). Gene expression of TRF2 and TERT were assessment by Real-time-PCR and the quantification of gene expression levels using the Pfaffl formula. Results: TRF2 gene significantly increased in HIIT and CET groups in compared to control group (P<0. 05). TERT gene non-significantly increased in HIIT and CET groups in compared to the control group. Conclusion: It seems, 6 weeks of high-intensity interval training and Continuous endurance training to be able regulate the growth and longevity of the heart cells by maintaining the length telomere by increasing TRF2 gene expression.

Cites

Effect of Resistance Exercise and Vitamin C Intake on Expression of Telomerase Reverse Transcriptase and Telomere Repeat Binding Factor-2 Genes and the Diameter and Number of Myofibrils in Old Rats

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APA: Copy

ESKANDARI, AREZOO, Fashi, Mohamad, & DAKHILI, AMIRBAHADOR. (2019). Effect of high intensity interval and continuous endurance training on TRF2 and TERT gene expression in heart tissue of aging male rats. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 21(2 (70) ), 43-49. SID. https://sid.ir/paper/406344/en

Vancouver: Copy

ESKANDARI AREZOO, Fashi Mohamad, DAKHILI AMIRBAHADOR. Effect of high intensity interval and continuous endurance training on TRF2 and TERT gene expression in heart tissue of aging male rats. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;21(2 (70) ):43-49. Available from: https://sid.ir/paper/406344/en

IEEE: Copy

AREZOO ESKANDARI, Mohamad Fashi, and AMIRBAHADOR DAKHILI, “Effect of high intensity interval and continuous endurance training on TRF2 and TERT gene expression in heart tissue of aging male rats,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. 2 (70) , pp. 43–49, 2019, [Online]. Available: https://sid.ir/paper/406344/en

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