Evaluation the Effect of Sea Cucumber (Holothuria leucospilota) on invA Gene Expression in Salmonella infantis

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GHASEMI N.; Falsafi s.; AMINI K.

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Journal: Pathobiology Research Year:2020 | Volume:23 | Issue:3 Page(s): 137-142

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Title

Evaluation the Effect of Sea Cucumber (Holothuria leucospilota) on invA Gene Expression in Salmonella infantis

Author(s)

GHASEMI N. | Falsafi s. | AMINI K. | Issue Writer Certificate

Keywords

Salmonella infantisQ1

Sea CucumberQ2

Antimicrobial ActivityQ1

Gene ExpressionQ2

Abstract

Aims Salmonellosis is one of the common infectious diseases between humans and animals that is caused by the consumption of poultry meat and its products. The invA gene plays a critical role in the pathogenicity of Salmonella infantis. Marine organisms, including Sea Cucumbers due to their effective secondary metabolites, have been identified and studied with compounds with antioxidant, anti-cancer, antibacterial, and anti-inflammatory properties. The aim of the current study is to determine effect of Sea Cucumber extraction on S. infantis invA Gene Expression. Materials & Methods Poultry meat was sampled and S. infantis strains containing invA gene were isolated. The Hexane extract was extracted from Sea Cucumber colon tissue and its effects on S. infantis and its effect on Gene Expression were investigated by MIC and Real-time PCR, respectively. Findings From 450 samples, 12 S. infantis isolates were isolated. The PCR technique identified that all 12 isolates have invA virulence genes. MIC was determined 256μ g/ml. The rate of change for the invA gene was estimated-1. 21. Conclusion Hexane extract extracted from the Sea Cucumber caused reduction of invA Gene Expression in Salmonella infantis. So, it can be used as a therapeutic supplement against S. infantis.

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APA: Copy

GHASEMI, N., Falsafi, s., & AMINI, K.. (2020). Evaluation the Effect of Sea Cucumber (Holothuria leucospilota) on invA Gene Expression in Salmonella infantis. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 23(3 ), 137-142. SID. https://sid.ir/paper/398442/en

Vancouver: Copy

GHASEMI N., Falsafi s., AMINI K.. Evaluation the Effect of Sea Cucumber (Holothuria leucospilota) on invA Gene Expression in Salmonella infantis. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2020;23(3 ):137-142. Available from: https://sid.ir/paper/398442/en

IEEE: Copy

N. GHASEMI, s. Falsafi, and K. AMINI, “Evaluation the Effect of Sea Cucumber (Holothuria leucospilota) on invA Gene Expression in Salmonella infantis,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 23, no. 3 , pp. 137–142, 2020, [Online]. Available: https://sid.ir/paper/398442/en

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