VACCINATION OF C57BL/6 MICE WITH TRANSGENIC LEISHMANIA MAJOR

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DOUSTI ABAS; DAVOUDI N.

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Journal: JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES Year:2008 | Volume:16 | Issue:64 Page(s): 60-66

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Title

VACCINATION OF C57BL/6 MICE WITH TRANSGENIC LEISHMANIA MAJOR

Author(s)

DOUSTI ABAS | DAVOUDI N. | Issue Writer Certificate

Keywords

LEISHMANIAQ3

LEISHMANIASISQ3

MICEQ3

TRANSGENICQ3

VACCINESQ3

Abstract

Introduction: LEISHMANIA is a kind of infection which arises of a mono cell. This disease prevalenced in topical countries of world. In despite of several studies which are done in overall the world, researchers didn't find an effective vaccination for it and common treatments didn't effective completely. Infect to LEISHMANIA create permanent immunity. Thus vaccination is the only cost-effective means to control LEISHMANIA.Objective: Assaying the obtained immunogenicity by vaccination of C57BL/6 MICE with TRANSGENIC LEISHMANIA major.Materials and Methods: In present study TRANSGENIC strain of L. major which express two suicide genes; thymidine kinase gene of Herpes Simplex Virus type 1 (HSV-tk) and cytosine deaminase gene of Saccharomyces cervisiea (Se-cd) in its genome have been used for vaccination of MICE. C57BL/6 MICE were infected by TRANSGENIC L. major and treated with gancic10vir and 5-fluorocytosine together.Result: The ELISA cytokine assay in this group showed high increase of IFN-g and low IL-4, next challenge in vaccination was blocked disease progression, which was due to high level of immunity.Conclusion: The inducible expression of suicide gene and drug can used as valuable method to find the safe and effective vaccine against LEISHMANIAsis.

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APA: Copy

DOUSTI, ABAS, & DAVOUDI, N.. (2008). VACCINATION OF C57BL/6 MICE WITH TRANSGENIC LEISHMANIA MAJOR. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, 16(64), 60-66. SID. https://sid.ir/paper/39854/en

Vancouver: Copy

DOUSTI ABAS, DAVOUDI N.. VACCINATION OF C57BL/6 MICE WITH TRANSGENIC LEISHMANIA MAJOR. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2008;16(64):60-66. Available from: https://sid.ir/paper/39854/en

IEEE: Copy

ABAS DOUSTI, and N. DAVOUDI, “VACCINATION OF C57BL/6 MICE WITH TRANSGENIC LEISHMANIA MAJOR,” JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, vol. 16, no. 64, pp. 60–66, 2008, [Online]. Available: https://sid.ir/paper/39854/en

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