DIPHTHERIA AND TETANUS IMMUNITY IN PLACENTA AND TWO MONTHS INFANT

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SAFAAR M.J.; KHALILIAN A.R.; AJAMI A.A.GH.; SAFAR H.; GHAHERI ABAS

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Title

DIPHTHERIA AND TETANUS IMMUNITY IN PLACENTA AND TWO MONTHS INFANT

Author(s)

Keywords

DIPHTHERIAQ3

TETANUS- PERTUSSIS VACCINEQ3

INFANTQ4

IMMUNITYQ2

PLACENTAQ3

PREGNANCYQ2

TETANUSQ3

TETANUS VACCINEQ3

Abstract

Introduction: Maternal immunization provides potential means for protecting INFANTs against some infections with universal application.Objective: This study was designed to determine the levels of IMMUNITY against DIPHTHERIA and TETANUS in mothers & their two months old INFANTs who referred for vaccination, and evaluate the relation of mothers vaccination on their INFANTs IMMUNITY and determine the ratio of mothers who didn’t observe the vaccination during PREGNANCY.Materials and Methods: Sera were collected from 110 mother-infant pairs before DTwP vaccination and from 69 INFANTs after receipt of three doses of DTP vaccine. Anti DIPHTHERIA, anti TETANUS toxins IgG levels were measured by ELIZA. History of DT vaccination of mothers at PREGNANCY was recorded. The mean concentration of antibodies against DIPHTHERIA and TETANUS in mother and their INFANTs before vaccination and in INFANTs after receipt of 3doses of DTwP vaccine were measured and compared by paired t-test.Results: Of 110 mothers, 22 (20%) did not receive dT vaccine. Of these 22 unvaccinated mothers, one (4.5%) and six (27.2%) were serologically susceptible to TETANUS and DIPHTHERIA respectively. The mean concentrations of antibodies titers of unvaccinated mothers were significantly lower than vaccinated mothers. All INFANTs acquired IMMUNITY against both infections after receipt of three doses of DTP vaccine. INFANTs’ immune response to DTP was not affected by maternal immunization.Conclusion: DIPHTHERIA – TETANUS toxoids components of DTP vaccine were highly immunologenic, According to lack of vaccination in PREGNANCY, more effort must be made to increase the coverage rate of this highly immunogenic vaccine to sustain protection against DIPHTHERIA and TETANUS.

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APA: Copy

SAFAAR, M.J., KHALILIAN, A.R., AJAMI, A.A.GH., SAFAR, H., & GHAHERI, ABAS. (2008). DIPHTHERIA AND TETANUS IMMUNITY IN PLACENTA AND TWO MONTHS INFANT. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, 17(65), 35-43. SID. https://sid.ir/paper/39864/en

Vancouver: Copy

SAFAAR M.J., KHALILIAN A.R., AJAMI A.A.GH., SAFAR H., GHAHERI ABAS. DIPHTHERIA AND TETANUS IMMUNITY IN PLACENTA AND TWO MONTHS INFANT. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2008;17(65):35-43. Available from: https://sid.ir/paper/39864/en

IEEE: Copy

M.J. SAFAAR, A.R. KHALILIAN, A.A.GH. AJAMI, H. SAFAR, and ABAS GHAHERI, “DIPHTHERIA AND TETANUS IMMUNITY IN PLACENTA AND TWO MONTHS INFANT,” JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, vol. 17, no. 65, pp. 35–43, 2008, [Online]. Available: https://sid.ir/paper/39864/en

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