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Information Journal Paper

Title

IMMUNE RESPONSE TO A SINGLE DOSE OF TETANUS TOXOID VACCINE IN HEMODIALYSIS PATIENTS

Pages

  13-16

Abstract

 Background: The incidence of infectious diseases is increased in patients with chronic renal failure. TETANUS ANTIBODY values are under the protective level in the elderly people, chronic haemodialysis patients, renal transplant recipients, and chronic renal failure. Most hemodialysis patients will develop an adequate anti-TETANUS ANTIBODY titer following administration of a single dose of tetanus vaccine. The aim of this study was to assess the immunity against tetanus in hemodialysis patients and to examine the immune response to a single dose of TETANUS TOXOID VACCINE. Material and methods: A clinical trial study (before-after) was designed in 54 hemodialysis patients who had been on dialysis for at least 3 months, three times a week. We described the experiment to the patients and received their consent. After a blood sample for anti-TETANUS ANTIBODY titer, single dose of TETANUS TOXOID VACCINE was administered. Repeat titers were obtained 8 week after the vaccination and analyzed by ELISA assay. Antibody levels equal to or greater than 0.1 IU/ml were considered protective.Results: 53 patients (98%) had inadequate antibody (0<0.1 IU/ml). After vaccination, 51 of 53 (96%) became immune with adequate antibody (> 0.1 IU/ml). There was a significant differences between titers of circulating antibodies were obtained before and after injection Td with Wilcoxon signed rank test (P<0.0001). Conclusion: This study showed the efficacy and safety of vaccination against tetanus in hemodialysis patients. 4% of patients had inadequate antibody after Td vaccination, therefore, hemodialysis patients will need revaccination much earlier, and tetanus toxoid antibody levels should be checked, if a patient is injured and potentially requires vaccination.

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    APA: Copy

    AMIN ZADEH, Z., POURKAZEMI, A., POURREZA GHOLI, F., KALANTAR, A., & GACHKAR, L.. (2006). IMMUNE RESPONSE TO A SINGLE DOSE OF TETANUS TOXOID VACCINE IN HEMODIALYSIS PATIENTS. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, 11(32), 13-16. SID. https://sid.ir/paper/52889/en

    Vancouver: Copy

    AMIN ZADEH Z., POURKAZEMI A., POURREZA GHOLI F., KALANTAR A., GACHKAR L.. IMMUNE RESPONSE TO A SINGLE DOSE OF TETANUS TOXOID VACCINE IN HEMODIALYSIS PATIENTS. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE[Internet]. 2006;11(32):13-16. Available from: https://sid.ir/paper/52889/en

    IEEE: Copy

    Z. AMIN ZADEH, A. POURKAZEMI, F. POURREZA GHOLI, A. KALANTAR, and L. GACHKAR, “IMMUNE RESPONSE TO A SINGLE DOSE OF TETANUS TOXOID VACCINE IN HEMODIALYSIS PATIENTS,” IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, vol. 11, no. 32, pp. 13–16, 2006, [Online]. Available: https://sid.ir/paper/52889/en

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