THE RELATIONSHIP OF XPC POLY AT SEQUENCE WITH BREAST CANCER

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GHASEMZADEH QAZVINI M.; SALEHI Z.; SAEIDI SAEDI H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES Year:2016 | Volume:25 | Issue:97 Page(s): 20-28

Download Full-Text

Persian Verion

View:

655

Download:

Cites:

Information Journal Paper

Title

THE RELATIONSHIP OF XPC POLY AT SEQUENCE WITH BREAST CANCER

Author(s)

GHASEMZADEH QAZVINI M. | SALEHI Z. | SAEIDI SAEDI H. | Issue Writer Certificate

Keywords

BREAST NEOPLASMSQ1

POLYMORPHISMQ1

GENETICQ2

XERODERMA PIGMENTOSUMQ2

Abstract

Introduction: Breast cancer is a malignant proliferation of epithelial cells that cover the breast ducts or lobes. The accumulation of DNA damage is considered as a major factor in breast cancer. One of the most important defense mechanisms is Nucleotide Excision Repair (NER). Dysregulation of DNA repair genes expression is important for breast carcinogenesis. XPC (Xeroderma pigmentosum, complementation group C) is an important NER gene that recognizes the damage caused by a variety of bulky DNA adducts. Poly AT (PAT) sequence is one of important POLYMORPHISMs in this gene.Objective: This study investigated the relationship of the XPC PAT POLYMORPHISM with breast cancer.Materials and Methods: In this Case-Control study, we analyzed 79 patients and 120 healthy controls. The genotyping of PAT POLYMORPHISM was performed using polymerase chain reaction (PCR) and statistical analyses were conducted by the MedCalc statistical software (version 12.1).Results: Among cancer cases, the distributions of PAT-/-, PAT-/+ and PAT+/+ genotypes were 66%, 10%, and 24%, respectively. Among controls, the distributions of PAT-/-, PAT-/+ and PAT+/+ genotypes were 71%, 19%, 10%, respectively. The genotype frequencies did differ significantly between patients and controls (P=0.01).The frequency of PAT+ allele was significantly higher in patients (0.30) than in the controls (0.20), (P=0.02).Conclusion: Our study suggests that XPC Poly AT sequence POLYMORPHISM might be a GENETIC predisposing factor for breast Cancer. However, larger population-based studies are needed for clarifying the role of XPC gene POLYMORPHISM in breast Cancer.

Cites

No record.

References

No record.

Cite

APA: Copy

GHASEMZADEH QAZVINI, M., SALEHI, Z., & SAEIDI SAEDI, H.. (2016). THE RELATIONSHIP OF XPC POLY AT SEQUENCE WITH BREAST CANCER. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, 25(97), 20-28. SID. https://sid.ir/paper/39889/en

Vancouver: Copy

GHASEMZADEH QAZVINI M., SALEHI Z., SAEIDI SAEDI H.. THE RELATIONSHIP OF XPC POLY AT SEQUENCE WITH BREAST CANCER. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;25(97):20-28. Available from: https://sid.ir/paper/39889/en

IEEE: Copy

M. GHASEMZADEH QAZVINI, Z. SALEHI, and H. SAEIDI SAEDI, “THE RELATIONSHIP OF XPC POLY AT SEQUENCE WITH BREAST CANCER,” JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 97, pp. 20–28, 2016, [Online]. Available: https://sid.ir/paper/39889/en

Related Journal Papers