High-Density Lipoprotein Measurement Methods: From Precipitation to Nuclear Magnetic Resonance (NMR)

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HOSSEINZADEH S.; Pakizehkar S.; HEDAYATI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2020 | Volume:22 | Issue:1 Page(s): 11-29

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Information Journal Paper

Title

High-Density Lipoprotein Measurement Methods: From Precipitation to Nuclear Magnetic Resonance (NMR)

Author(s)

HOSSEINZADEH S. | Pakizehkar S. | HEDAYATI M. | Issue Writer Certificate

Keywords

CholesterolQ1

HDLQ2

Risk AssessmentQ1

Cardiovascular DiseaseQ1

Coronary Artery DiseaseQ1

ArteriosclerosisQ1

Abstract

Introduction: Extensive research suggests a common hypothesis regarding the protective role of total high-density lipoprotein-Cholesterol (HDL-C) against Cardiovascular Disease (CVD). This hypothesis indicates an inverse relationship between CVD and high HDL-C levels. Various mechanisms, such as reverse Cholesterol transport, besides anti-inflammatory and antioxidant functions, indicate HDL-C as one of the potential predictors of CVD risk. Therefore, it is important to be familiar with different methods of HDL-C measurement and to evaluate their advantages and disadvantages. In this study, after reviewing the nature, function, and protective role of HDL-C against CVD, the HDL-C measurement methods were evaluated. Also, some interfering molecules due to interventions and some strategies to reduce interference were discussed. It seems that the increased use of homogenous measurement methods is related to some disadvantages, such as high cost, manual separation, time-consuming design, and structure manipulation, in first-and second-generation chemical methods, as well as methods based on physical properties. On the other hand, targeted assessment of HDL-C function and protective role can be a novel approach to predict the risk of CVD. However, all of these methods require further improvement and optimization.

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APA: Copy

HOSSEINZADEH, S., Pakizehkar, S., & HEDAYATI, M.. (2020). High-Density Lipoprotein Measurement Methods: From Precipitation to Nuclear Magnetic Resonance (NMR). IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 22(1 ), 11-29. SID. https://sid.ir/paper/400056/en

Vancouver: Copy

HOSSEINZADEH S., Pakizehkar S., HEDAYATI M.. High-Density Lipoprotein Measurement Methods: From Precipitation to Nuclear Magnetic Resonance (NMR). IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2020;22(1 ):11-29. Available from: https://sid.ir/paper/400056/en

IEEE: Copy

S. HOSSEINZADEH, S. Pakizehkar, and M. HEDAYATI, “High-Density Lipoprotein Measurement Methods: From Precipitation to Nuclear Magnetic Resonance (NMR),” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 22, no. 1 , pp. 11–29, 2020, [Online]. Available: https://sid.ir/paper/400056/en

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