The effect of the forced treadmill running on genes expression of the PGC-1α , FNDC5 and BDNF in hippocampus of male rats

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Azimi Dokht Seyyed Mohammad Ali; GHARAKHANLOU REZA; NAGHDI NASSER; KHODADADI DAVAR; Zarezadehmehrizi Aliasghar

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Journal: JOURNAL OF PRACTICAL STUDIES AT BIOSCIENCES IN SPORT Year:2020 | Volume:7 | Issue:14 Page(s): 91-101

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Title

The effect of the forced treadmill running on genes expression of the PGC-1α , FNDC5 and BDNF in hippocampus of male rats

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Keywords

Low-intensity forced trainingQ1

Gene PGC-1αQ1

Gene FNDC5Q1

Gene BDNFQ1

Rat hippocampusQ1

Abstract

Background and Aim: Previous studies have shown that brain-derived neurotrophic factor (BDNF) plays a vital role to induce the beneficial effects of exercise on the brain, especially the hippocampus. However, signaling pathways related to increasing BDNF induced by forced exercise in hippocampus not well known. Therefore, the purpose of current study was to investigate the effect of 8-week of low-intensity forced treadmill training on genes expression of peroxisome proliferator activated receptor-gamma co-activator 1-alpha (PGC-1α ), fibronectin type III domain containing 5 (FNDC5) and BDNF in hippocampus of male rats. Materials and Methods: Eighteen male Wistar rats were randomly divided into 3 groups including control (n=6), sham (n=6) and forced training (n=6). Animals in the training group performed 8 weeks of forced training (5 sessions per week) with low-intensity (speed: 15 m/min) on the treadmill. Twenty-four hours after last session of exercise, rats were decapitated and the hippocampus were carefully removed and rapidly frozen in liquid nitrogen, and finally stored at-80° C for further analysis. Real-Time-PCR method was used to measure the expression of genes in the hippocampus. Data were analyzed by one way ANOVA and Tukey post hoc test at the significant level of p<0. 05. Results: The results showed that mRNA levels of PGC-1α (p<0. 003), FNDC5 (p<0. 006) and BDNF (p<0. 02) in the forced training group were significantly higher than the control group. However, there was no significant difference in the mRNA levels of genes between the sham and control groups (p>0. 05). Conclusion: It seems that the Low-intensity forced training, likely through a PGC-1α-dependent signaling pathway, leads to increasing expression of FNDC5 and as a result causes increasing the expression of BDNF. Thus, this type of exercise training can be used as induction of beneficial effects of exercise on the hippocampus.

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APA: Copy

Azimi Dokht, Seyyed Mohammad Ali, GHARAKHANLOU, REZA, NAGHDI, NASSER, KHODADADI, DAVAR, & Zarezadehmehrizi, Aliasghar. (2020). The effect of the forced treadmill running on genes expression of the PGC-1α , FNDC5 and BDNF in hippocampus of male rats. JOURNAL OF PRACTICAL STUDIES AT BIOSCIENCES IN SPORT, 7(14 ), 91-101. SID. https://sid.ir/paper/400531/en

Vancouver: Copy

Azimi Dokht Seyyed Mohammad Ali, GHARAKHANLOU REZA, NAGHDI NASSER, KHODADADI DAVAR, Zarezadehmehrizi Aliasghar. The effect of the forced treadmill running on genes expression of the PGC-1α , FNDC5 and BDNF in hippocampus of male rats. JOURNAL OF PRACTICAL STUDIES AT BIOSCIENCES IN SPORT[Internet]. 2020;7(14 ):91-101. Available from: https://sid.ir/paper/400531/en

IEEE: Copy

Seyyed Mohammad Ali Azimi Dokht, REZA GHARAKHANLOU, NASSER NAGHDI, DAVAR KHODADADI, and Aliasghar Zarezadehmehrizi, “The effect of the forced treadmill running on genes expression of the PGC-1α , FNDC5 and BDNF in hippocampus of male rats,” JOURNAL OF PRACTICAL STUDIES AT BIOSCIENCES IN SPORT, vol. 7, no. 14 , pp. 91–101, 2020, [Online]. Available: https://sid.ir/paper/400531/en

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