Antioxidant activity and Cytotoxicity Effect of Various Extracts of Sclerorhachis platyrachis on the Human breast adenocarcinoma Cells

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REZAEI SERESHT HASAN; CHESHOMI HAMID; ALDAGHI LEILASADAT; Kaskani Arezou

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Journal: SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES Year:2020 | Volume:25 | Issue:1 (105) Page(s): 33-42

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Title

Antioxidant activity and Cytotoxicity Effect of Various Extracts of Sclerorhachis platyrachis on the Human breast adenocarcinoma Cells

Author(s)

REZAEI SERESHT HASAN | CHESHOMI HAMID | ALDAGHI LEILASADAT | Kaskani Arezou | Issue Writer Certificate

Keywords

Sclerorhachis platyrachisQ1

ExtractQ2

HEK293 cell lineQ1

1Q1

1-DPPHQ1

Abstract

Background and Aim: One of the spices of compositae is the Sclerorhachis platyrachis that is Iranian native. This aromatic plant has been known as bacterial growth inhibitor. This study have been attempted to investigate antioxidant activity and cytotoxicity effect of Sclerorhachis platyrachis Extractson the MCF-7 cell line. Materials and Methods: The Hexane (HE), Chloroform (CE), Ethyl acetate (EE), Methanolic Extracts (ME) of Sclerorhachis platyrachis leaves prepared by usingmaceration method. The DPPH assay was used for determination of antioxidant activity. Also, total phenolic content measured. The cytotoxicity of the Extracts on MCF-7 and HEK-293 cells evaluated using MTT assay in both 48h and 72h. Results: evaluation of antioxidant activity indicated that radical scavenging ability was as ascorbic acid> ME > EE > CE > HE, While, total phenolic content was as CE>ME>EE>HE. The highest and the lowest cytotoxicity against MCF-7 cells were related to CE and ME respectively. Except for ethyl acetate Extract, all Extract were non toxic on the HEK-293 cells. Conclusion: Our findings showed that the chloroform Extract of aerial part of Sclerorhachis platyrachis had the strongest effect against breast cancer carcinoma (MCF-7). Whereas, the Extracts of this plant had no cytotoxicity on the normal cells.

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APA: Copy

REZAEI SERESHT, HASAN, CHESHOMI, HAMID, ALDAGHI, LEILASADAT, & Kaskani, Arezou. (2020). Antioxidant activity and Cytotoxicity Effect of Various Extracts of Sclerorhachis platyrachis on the Human breast adenocarcinoma Cells. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 25(1 (105) ), 33-42. SID. https://sid.ir/paper/400565/en

Vancouver: Copy

REZAEI SERESHT HASAN, CHESHOMI HAMID, ALDAGHI LEILASADAT, Kaskani Arezou. Antioxidant activity and Cytotoxicity Effect of Various Extracts of Sclerorhachis platyrachis on the Human breast adenocarcinoma Cells. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;25(1 (105) ):33-42. Available from: https://sid.ir/paper/400565/en

IEEE: Copy

HASAN REZAEI SERESHT, HAMID CHESHOMI, LEILASADAT ALDAGHI, and Arezou Kaskani, “Antioxidant activity and Cytotoxicity Effect of Various Extracts of Sclerorhachis platyrachis on the Human breast adenocarcinoma Cells,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 1 (105) , pp. 33–42, 2020, [Online]. Available: https://sid.ir/paper/400565/en

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