ANTI-PROLIFERATION EFFECTS OF SCROPHULARIA OXYSEPALA MEDICINAL PLANT EXTRACT ON THE 4T1 MOUSE BREAST CANCER CELL LINE

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CHOKHACHI BARADARAN POONEH; BARADARAN BEHZAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Studies in Medical Sciences Year:2017 | Volume:27 | Issue:10 Page(s): 871-881

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Title

ANTI-PROLIFERATION EFFECTS OF SCROPHULARIA OXYSEPALA MEDICINAL PLANT EXTRACT ON THE 4T1 MOUSE BREAST CANCER CELL LINE

Author(s)

CHOKHACHI BARADARAN POONEH | BARADARAN BEHZAD | Issue Writer Certificate

Keywords

SCROPHULARIA OXYSEPALAQ1

MOUSE BREAST CANCERQ1

CYTOTOXICITYQ1

APOPTOSISQ2

4T1Q1

Abstract

Background & Aims: Medical plants have been intensively studied as a source of antitumor compounds.The antitumor effects of the SCROPHULARIA OXYSEPALA medicinal plant extract is not studied on the 4T1 MOUSE BREAST CANCER cell lines. In the present study, cytotoxic effects of the SCROPHULARIA OXYSEPALA extract were investigated on viability of 4T1 cells, MOUSE BREAST CANCER cell line.Materials & Methods: The cytotoxic effects of SCROPHULARIA OXYSEPALA on 4T1 cells were studied using MTT assay, Trypan blue staining, and DNA fragmentation assay were done at selected concentrations of the plant extract.Results: According to the findings, the SCROPHULARIA OXYSEPALA medicinal plant extract (stems and leaves) can alter cells morphology. So the SCROPHULARIA OXYSEPALA extract inhibits cell growth albeit in a time and dose dependent manner and results in degradation of chromosomal DNA.Conclusion: Our data well established the anti-proliferative effect of SCROPHULARIA OXYSEPALA extract, and clearly showed that the plant extract can induce APOPTOSIS in vitro, but the mechanism of its activities remained unclear.

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APA: Copy

CHOKHACHI BARADARAN, POONEH, & BARADARAN, BEHZAD. (2017). ANTI-PROLIFERATION EFFECTS OF SCROPHULARIA OXYSEPALA MEDICINAL PLANT EXTRACT ON THE 4T1 MOUSE BREAST CANCER CELL LINE. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 27(10), 871-881. SID. https://sid.ir/paper/64337/en

Vancouver: Copy

CHOKHACHI BARADARAN POONEH, BARADARAN BEHZAD. ANTI-PROLIFERATION EFFECTS OF SCROPHULARIA OXYSEPALA MEDICINAL PLANT EXTRACT ON THE 4T1 MOUSE BREAST CANCER CELL LINE. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2017;27(10):871-881. Available from: https://sid.ir/paper/64337/en

IEEE: Copy

POONEH CHOKHACHI BARADARAN, and BEHZAD BARADARAN, “ANTI-PROLIFERATION EFFECTS OF SCROPHULARIA OXYSEPALA MEDICINAL PLANT EXTRACT ON THE 4T1 MOUSE BREAST CANCER CELL LINE,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 27, no. 10, pp. 871–881, 2017, [Online]. Available: https://sid.ir/paper/64337/en

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