HEPATITIS VIRUSES SEROMARKERS AND LIVER FUNCTION IN GUILAN HEMOPHILIACS

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MANSOUR GHANAEI F.; FOROUTAN H.; FALAH M.S.; SHAFAGHI A.; POURSHAMS A.; RAMEZANI N.; FARZANEH F.; YOUSEFI MAHMOUD

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Journal: JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES Year:2002 | Volume:10 | Issue:39-40 Page(s): 56-64

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Title

HEPATITIS VIRUSES SEROMARKERS AND LIVER FUNCTION IN GUILAN HEMOPHILIACS

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Keywords

ALANINE AMINOTRANSFERASEQ4

HEMOPHILIAQ4

HEPATITIS B SURFACE ANTIGENQ4

HEPATITIS C ANTIBODIESQ3

Abstract

There are some reports about hepatitis B and C Virus infection in HEMOPHILIAcs in different part of our country. We studied Guilan Province HEMOPHILIAcs to determine the frequency of HEPATITIS B SURFACE ANTIGEN (HbsAg), anti hepatitis C antibody and liver function test impairments. This study was done from Feb to Apr 1999 among HEMOPHILIAcs registered in Guilan HEMOPHILIA Society. Patients were examined for anti hepatitis C antibody (Radio immunblot assay (RIBA-II) method), HEPATITIS B SURFACE ANTIGEN (Enzyme linked Immunosorbant Assay (ELIZA)) and liver function tests. 101 patients included. Mean age was 19.7 years old (Range 3-71 years old), 100 patients were male and one female. 29 patients (28.7%) had increased serum level of Alanine Aminotransfrase (ALT). 27 patient (26.7%) were HbsAg positive and 72 patient(71.3%) were Anti HCV -Ab positive. Duration of clotting factor receiving until 1376 (1996) had an association with positive Anti HCV-Ab (P=0.01) but not with positive HbsAg or increased ALT. Clotting factor activity had an association with positive Anti HCV-Ab (P<0.001) and positive HbsAg (P<0.04). Frequency of positive anti HCV-Ab in who had received leophilized Factor VIII and Cryoprecipitate Factor VIII or Factor IX and Fresh Frozen Plasma (FFP) was greater than who had received only leophilized factor VIII or FFP.(p<0.01). Frequency of HbsAg positive patients was more than what we expected. Vaccination against hepatitis B virus after diagnosis of HEMOPHILIA is advised. Although Anti HCV -Ab. frequency was similar to other studies, frequency of increased AL T was less. Because of high chronicity of hepatitis C Virus, diagnose and treat Anti HCV positive patients are suggested.

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APA: Copy

MANSOUR GHANAEI, F., FOROUTAN, H., FALAH, M.S., SHAFAGHI, A., POURSHAMS, A., RAMEZANI, N., FARZANEH, F., & YOUSEFI, MAHMOUD. (2002). HEPATITIS VIRUSES SEROMARKERS AND LIVER FUNCTION IN GUILAN HEMOPHILIACS . JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, 10(39-40), 56-64. SID. https://sid.ir/paper/40227/en

Vancouver: Copy

MANSOUR GHANAEI F., FOROUTAN H., FALAH M.S., SHAFAGHI A., POURSHAMS A., RAMEZANI N., FARZANEH F., YOUSEFI MAHMOUD. HEPATITIS VIRUSES SEROMARKERS AND LIVER FUNCTION IN GUILAN HEMOPHILIACS . JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2002;10(39-40):56-64. Available from: https://sid.ir/paper/40227/en

IEEE: Copy

F. MANSOUR GHANAEI, H. FOROUTAN, M.S. FALAH, A. SHAFAGHI, A. POURSHAMS, N. RAMEZANI, F. FARZANEH, and MAHMOUD YOUSEFI, “HEPATITIS VIRUSES SEROMARKERS AND LIVER FUNCTION IN GUILAN HEMOPHILIACS ,” JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, vol. 10, no. 39-40, pp. 56–64, 2002, [Online]. Available: https://sid.ir/paper/40227/en

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