EFFECT OF SYSTEMIC INJECTION OF VASOPRESSIN ON ANXIETY IN PLUS MAZE IN MICE

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MILADI GORJI H.; VAFAEI A.A.

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Paper Information

Journal: JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES Year:2005 | Volume:14 | Issue:53 Page(s): 14-15

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Title

EFFECT OF SYSTEMIC INJECTION OF VASOPRESSIN ON ANXIETY IN PLUS MAZE IN MICE

Author(s)

MILADI GORJI H. | VAFAEI A.A. | Issue Writer Certificate

Keywords

ANXIETYQ2

MICEQ2

VASOPRESSINSQ4

Abstract

Introduction: Previous studies indicated that vasopressin as a neurotransmitter can have a role in modulation of ANXIETY reactions. Objective: The present study was designed to evaluate the role of vasopressin as a neurotransmitter on the fear and ANXIETY in plus maze model. Materials and Methods: Male albino MICE (mean weight of 25-30 g) were used for these experiments. First animals were randomly divided into three control and experimental groups. Then 5-10 μg/kg vasopressin was administered to experimental group and same amount of normal saline was given to control group ten minutes before the experiment. And in order to increase their movement and curiosity, they were put inside the black wall box for 5 min. Then animals were transferred to the Plus Maze and evaluated their ANXIETY reaction through observing the standard index of ANXIETY assessment.Results: Results indicated that injection of vasopressin in both doses reduced ANXIETY reaction as compared to saline group and in the test group animals have more number of entrances and spent more time in open arm (P<0.01).Conclusion: The above results show that vasopressin plays an important role in reduction of ANXIETY in Plus Maze model.

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APA: Copy

MILADI GORJI, H., & VAFAEI, A.A.. (2005). EFFECT OF SYSTEMIC INJECTION OF VASOPRESSIN ON ANXIETY IN PLUS MAZE IN MICE . JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, 14(53), 14-15. SID. https://sid.ir/paper/40270/en

Vancouver: Copy

MILADI GORJI H., VAFAEI A.A.. EFFECT OF SYSTEMIC INJECTION OF VASOPRESSIN ON ANXIETY IN PLUS MAZE IN MICE . JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2005;14(53):14-15. Available from: https://sid.ir/paper/40270/en

IEEE: Copy

H. MILADI GORJI, and A.A. VAFAEI, “EFFECT OF SYSTEMIC INJECTION OF VASOPRESSIN ON ANXIETY IN PLUS MAZE IN MICE ,” JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, vol. 14, no. 53, pp. 14–15, 2005, [Online]. Available: https://sid.ir/paper/40270/en

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