THE EFFECT OF DEXAMETHASONE ON ANXIETY RELATED BEHAVIOR IN MICE

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VAFAEI A.A.; MILADI GORJI H.; TAHERIAN ABAS ALI; RASHIDIPOUR A.

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Journal: JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES Year:2007 | Volume:5 | Issue:4 (21) Page(s): 285-290

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Title

THE EFFECT OF DEXAMETHASONE ON ANXIETY RELATED BEHAVIOR IN MICE

Author(s)

VAFAEI A.A. | MILADI GORJI H. | TAHERIAN ABAS ALI | RASHIDIPOUR A. | Issue Writer Certificate

Keywords

ANXIETYQ2

GLUCOCORTICOIDSQ3

DEXAMETHASONEQ3

MICEQ2

Abstract

Background and Objective: Previous studies have suggested that activation of the glucocorticoid receptors may have a modulatory effect on fear and ANXIETY. Therefore, the aim of this study was to determine the role of glucocorticoid hormones on modulation of ANXIETY in elevated plus-maze model in MICE.Materials and Methods: In this experimental study, 60 male MICE (25-30 g) were included. They were randomely divided into test and control groups. The test group received different doses of DEXAMETHASONE, as an agonist of glucocorticoid receptors, at 0.1, 0.3, 1, 2 and 10 mg/kg, Subcutaneously, and the control group received the same volume of 2% ethanol in normal saline 30 minutes before the evaluation of their behavior. Twenty five minutes after the injection, the MICE were put in a black box for 5 minutes to induce their activity and stress. The animals were then individually transferred to a standard elevated pluse-maze in regulated time and the percentage of time spent in the open arms and the ratio of open arm entries to total entries in 5 mins was measured.Results: Results indicated that DEXAMETHASONE with the doses 0.3 and 1mg/kg, significantly reduced ANXIETY in MICE (p<0.01). However, this effect was not observed at 0.1 and 2mg/kg. Our findings also showed that denamechasone at the dose of 10mg/kg increased ANXIETY behavior in MICE (p<0.01).Conclusion: The findings of this study indicated that GLUCOCORTICOIDS have important role in modulation of ANXIETY related behavior in a dose dependent manner using an elevated plus maze model in MICE.

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References

POSSIBLE INVOLVEMENT OF NITRIC OXIDE (NO) IN ANXIETY-LIKE BEHAVIOR INDUCED BY FEMALE STEROID HORMONES

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APA: Copy

VAFAEI, A.A., MILADI GORJI, H., TAHERIAN, ABAS ALI, & RASHIDIPOUR, A.. (2007). THE EFFECT OF DEXAMETHASONE ON ANXIETY RELATED BEHAVIOR IN MICE. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 5(4 (21)), 285-290. SID. https://sid.ir/paper/392511/en

Vancouver: Copy

VAFAEI A.A., MILADI GORJI H., TAHERIAN ABAS ALI, RASHIDIPOUR A.. THE EFFECT OF DEXAMETHASONE ON ANXIETY RELATED BEHAVIOR IN MICE. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2007;5(4 (21)):285-290. Available from: https://sid.ir/paper/392511/en

IEEE: Copy

A.A. VAFAEI, H. MILADI GORJI, ABAS ALI TAHERIAN, and A. RASHIDIPOUR, “THE EFFECT OF DEXAMETHASONE ON ANXIETY RELATED BEHAVIOR IN MICE,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 5, no. 4 (21), pp. 285–290, 2007, [Online]. Available: https://sid.ir/paper/392511/en

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