STUDY OF THE BONE DEFECT REPAIR USING BONE MARROW STROMAL CELLS AND GELATIN-CHITOSAN MEMBRANE IN RAT

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AJOUDANI A.; SADOUGHI M.; SADRAIE S.H.; KAKA GH.R.

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Paper Information

Journal: JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES Year:2016 | Volume:24 | Issue:96 Page(s): 68-78

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Title

STUDY OF THE BONE DEFECT REPAIR USING BONE MARROW STROMAL CELLS AND GELATIN-CHITOSAN MEMBRANE IN RAT

Author(s)

AJOUDANI A. | SADOUGHI M. | SADRAIE S.H. | KAKA GH.R. | Issue Writer Certificate

Keywords

BONEQ3

CELL TRANSPLANSQ2

GELATINQ2

MESENCHYMAL STROMAL CELLSQ2

RATSQ2

Abstract

Introduction: BONE marrow stromal cells (BMSCs) are multipotent stem cells that can differentiate into osteogenic cells. Today, biocompatible scaffold has emerged as a novel treatment for replacement of lost BONE tissue.Objective: This study evaluated the repairment of BONE defect using BONE marrow stromal cells and GELATIN-chitosan membrane in RATS.Materials and Methods: In this experimental study, sixty male adult Albino Wistar RATS were equally divided into five groups as follows: Group 1 (control group) received no treatment after BONE defect. Group 2 (sham group) after BONE defect, the culture medium was injected at the site of BONE defect. Group 3 (gelatin-chitosan group), with GELATINchitosan membrane used into BONE defect. Group 4 with BMSCs transplanted into BONE defect and Group 5 with cell transplantation with chitosan-gelatin membrance used into BONE defect.Results: No significant difference was found between the controls and Sham group, according to radiopacity test but radiograph BONE opacity increased in chitosan-gelatin and cell groups, compared to control group but the differences were not significant. On the other hand, in cell-GC group compared to control group, radiopacity decreased but was not significant. Our biomechanical results showed the mean of F max was significantly increased in cell group compared to control group, and in GELATIN-Chitosan group compared to control group was increased but the difference was not significant and in cell-GC group compared to control group it was decreased but the difference was not significant, either.Conclusion: It seems that GELATIN-chitosan membrane transplantation can partly be useful for repairing of BONE defect. Although the use of BONE marrow stromal cells with the membrane could help a little to repair of BONE defects, cell transplantation alone is better for repairing the BONE defects.

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