EFFECT OF OREXIN RECEPTOR-1 AGONIST AND ANTAGONIST MICROINJECTION INTO THE VENTRAL TEGMENTAL AREA ON MORPHINE WITHDRAWAL SYNDROME

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ESMAEILI M.H.; AZHDARI ZARMEHRI H.; HAGHDOST H.; SOFIABADI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Inflammatory Diseases Year:2013 | Volume:17 | Issue:3 (68) Page(s): 4-11

Download Full-Text

Persian Verion

View:

899

Download:

Cites:

Information Journal Paper

Title

EFFECT OF OREXIN RECEPTOR-1 AGONIST AND ANTAGONIST MICROINJECTION INTO THE VENTRAL TEGMENTAL AREA ON MORPHINE WITHDRAWAL SYNDROME

Author(s)

ESMAEILI M.H. | AZHDARI ZARMEHRI H. | HAGHDOST H. | SOFIABADI M. | Issue Writer Certificate

Keywords

OREXINQ1

VENTRAL TEGMENTAL AREA (VTA)Q2

MORPHINE DEPENDENCEQ3

SUBSTANCE WITHDRAWAL SYNDROMEQ2

Abstract

Background: Several Studies have identified that the mesocorticolimbic dopaminergic pathway consisting of the ventral tegmental area (VTA) and the nucleus accumbens (NAc) plays an important role in MORPHINE DEPENDENCE and withdrawal signs. OREXIN projection and its receptors have been found in the brain regions including VTA that involved in the expression of morphine withdrawal signs.Objective: The aim of this study was to evaluate the effects of OREXIN receptor-1 (OX1R) agonist and antagonist microinjection into the VTA on withdrawal signs in morphine dependent rats.Methods: This experimental study was carried out on 24 male Wistar rats (weighing 250-300 g) in 2012 that were divided in 4 groups. They were rendered morphine dependent by subcutaneous injection of morphine sulfate at intervals of 12 h for 10 days. On day 11, intra-VTA microinjection of OREXIN receptor-1 agonist (OREXIN-A) and antagonist (SB-334867) was performed (2h after last morphine injection and before naloxan injection) and naloxone precipitated withdrawal sings were evaluated for 30 min. In the vehicle group, normal salin was microinjected into the VTA. Data were analyzed using t-test and ANOVA.Findings: Intra-VTA SB-334867 microinjection significantly decreased the jumping sign (P<0.01). OREXIN-A microinjection significantly increased the wet-dog shakes sign (P<0.05).Conclusion: With regard to the results, OX1R in the VTA has a little effect on expression of withdrawal signs in morphine dependent rats.

Cites

No record.

References

No record.

Cite

APA: Copy

ESMAEILI, M.H., AZHDARI ZARMEHRI, H., HAGHDOST, H., & SOFIABADI, M.. (2013). EFFECT OF OREXIN RECEPTOR-1 AGONIST AND ANTAGONIST MICROINJECTION INTO THE VENTRAL TEGMENTAL AREA ON MORPHINE WITHDRAWAL SYNDROME. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), 17(3 (68)), 4-11. SID. https://sid.ir/paper/402897/en

Vancouver: Copy

ESMAEILI M.H., AZHDARI ZARMEHRI H., HAGHDOST H., SOFIABADI M.. EFFECT OF OREXIN RECEPTOR-1 AGONIST AND ANTAGONIST MICROINJECTION INTO THE VENTRAL TEGMENTAL AREA ON MORPHINE WITHDRAWAL SYNDROME. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2013;17(3 (68)):4-11. Available from: https://sid.ir/paper/402897/en

IEEE: Copy

M.H. ESMAEILI, H. AZHDARI ZARMEHRI, H. HAGHDOST, and M. SOFIABADI, “EFFECT OF OREXIN RECEPTOR-1 AGONIST AND ANTAGONIST MICROINJECTION INTO THE VENTRAL TEGMENTAL AREA ON MORPHINE WITHDRAWAL SYNDROME,” JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), vol. 17, no. 3 (68), pp. 4–11, 2013, [Online]. Available: https://sid.ir/paper/402897/en

Related Journal Papers