Synergic effects of Summer Savory extract and aspirin on human platelets function

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YASINI MAHYA SADAT; HAMIDPOUR MOHSEN; Ayatollahi Abdollmajid; SHAHMEHRI MASOUD; Kehanpour Nasrin

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Journal: Koomesh Year:2019 | Volume:21 | Issue:3 (75) Page(s): 503-508

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Title

Synergic effects of Summer Savory extract and aspirin on human platelets function

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Keywords

Platelet AggregationQ2

Platelet AdhesionQ1

Summer SavoryQ2

AspirinQ1

Abstract

Introduction: Cardiovascular disease is one of the most common diseases in the world. In this account, atherosclerosis is one of the main cause’ s heart attacks. Coagulation activity of platelets plays an important role in atherosclerotic plaque formation, thrombosis formation and cardiovascular diseases. Aspirin is the most commonly drugs which used as anti-platelet function to prevent and treat cardiovascular diseases. Long-term using of Aspirin sometimes has irreparable consequences, resulting in medicine doctors, have been recommended using of herbal medicine as a complementary drug. The present study was aimed to investigate the effect of Summer Savory extract and Aspirin on platelets function. Materials and Methods: Platelets were prepared from male healthy volunteers. The platelets were treated with concentrations (250-1000 µ g/ml) of Summer Savory extraction and Aspirin (0. 31 – 1. 26 µ g/ml) to investigate platelet function. We applied aggregometry test to determine Platelet Aggregation and ELISA assay to determine Platelet Adhesion and protein secretion. Results: The extract of Summer Savory at a concentration of 1000 µ g/ml alone inhibited the platelets acvitity by 73%, and at a concentration of 500 µ g/ml and with Aspirin at a concentration of 0. 63 µ g/ml inhibited platelets function by 52% than control (P< 0. 001). Conclusion: Considering the synergic antiplatelet effects of Summer Savory extract and Aspirin, it is recommended to use this extract as an appropriate anti-platelet supplement with a low dose of Aspirin for cardiac patients.

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APA: Copy

YASINI, MAHYA SADAT, HAMIDPOUR, MOHSEN, Ayatollahi, Abdollmajid, SHAHMEHRI, MASOUD, & Kehanpour, Nasrin. (2019). Synergic effects of Summer Savory extract and aspirin on human platelets function. KOOMESH, 21(3 (75) ), 503-508. SID. https://sid.ir/paper/403410/en

Vancouver: Copy

YASINI MAHYA SADAT, HAMIDPOUR MOHSEN, Ayatollahi Abdollmajid, SHAHMEHRI MASOUD, Kehanpour Nasrin. Synergic effects of Summer Savory extract and aspirin on human platelets function. KOOMESH[Internet]. 2019;21(3 (75) ):503-508. Available from: https://sid.ir/paper/403410/en

IEEE: Copy

MAHYA SADAT YASINI, MOHSEN HAMIDPOUR, Abdollmajid Ayatollahi, MASOUD SHAHMEHRI, and Nasrin Kehanpour, “Synergic effects of Summer Savory extract and aspirin on human platelets function,” KOOMESH, vol. 21, no. 3 (75) , pp. 503–508, 2019, [Online]. Available: https://sid.ir/paper/403410/en

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