THE ROLE OF ESTROGEN AND PROGESTERONE RECEPTORS IN RESPONSE RATE TO MEGESTROL ACETATE: CONSERVATIVE TREATMENT OF STAGE IA ENDOMETRIAL ADENOCARCINOMA

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YARANDI FARIBA; SHIRALI ELHAM; EFTEKHAR ZAHRA; KHAZAEIPOUR ZAHRA

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Journal: Tehran University Medical Journal Year:2010 | Volume:68 | Issue:9 Page(s): 541-546

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Title

THE ROLE OF ESTROGEN AND PROGESTERONE RECEPTORS IN RESPONSE RATE TO MEGESTROL ACETATE: CONSERVATIVE TREATMENT OF STAGE IA ENDOMETRIAL ADENOCARCINOMA

Author(s)

YARANDI FARIBA | SHIRALI ELHAM | EFTEKHAR ZAHRA | KHAZAEIPOUR ZAHRA | Issue Writer Certificate

Keywords

ENDOMETRIAL ADENOCARCINOMAQ3

MEGESTROL ACETATEQ3

WELLQ3

Abstract

Background: Surgery is the most effective treatment of WELL-differentiated endometrial cancer. But using systemic progestins, have been evaluated to treat the young patients with WELL-differentiated endometrial cancer who wish to preserve their fertility. The aim of this study was the evaluation of MEGESTROL ACETATE on ENDOMETRIAL ADENOCARCINOMA with regard to the receptors.Methods: This was a quasi-experimental study. In 16 infertile patients with stage Ia WELL-differentiated ENDOMETRIAL ADENOCARCINOMA. The treatment initiated with 160mg/d of MEGESTROL ACETATE and continued with 320mg/d for non-responsive cases. All of the patients followed with FD& C and hysteroscopy. The responsive patients were referred to IVF group and they were followed for three years.Results: Of nine patient in the first step of the study, 4 (25%) became pregnant. Eight patients underwent Total Abdominal Hysterectomy (TAH), and one was retreated conservatively. Of seven patient of second step of the study, five are under treatment at the time of closing the paper (three cases candidate for IVF and two are under 320 mg/d MEGESTROL ACETATE), one patient is a candidate for hysterectomy, and one exited of study because of male infertility. All of the patients were progesterone receptor positive, and only one was estrogen receptor negative.Conclusion: Conservative treatment of early stage WELL-differentiated ENDOMETRIAL ADENOCARCINOMA with progestins may be used in highly selected young patients who have not completed their family. Close long- term follow up in this special group of patients is necessary. The evaluation of estrogen and progesterone receptors assay may be useful in predicting response to the treatment.

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APA: Copy

YARANDI, FARIBA, SHIRALI, ELHAM, EFTEKHAR, ZAHRA, & KHAZAEIPOUR, ZAHRA. (2010). THE ROLE OF ESTROGEN AND PROGESTERONE RECEPTORS IN RESPONSE RATE TO MEGESTROL ACETATE: CONSERVATIVE TREATMENT OF STAGE IA ENDOMETRIAL ADENOCARCINOMA. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 68(9), 541-546. SID. https://sid.ir/paper/403891/en

Vancouver: Copy

YARANDI FARIBA, SHIRALI ELHAM, EFTEKHAR ZAHRA, KHAZAEIPOUR ZAHRA. THE ROLE OF ESTROGEN AND PROGESTERONE RECEPTORS IN RESPONSE RATE TO MEGESTROL ACETATE: CONSERVATIVE TREATMENT OF STAGE IA ENDOMETRIAL ADENOCARCINOMA. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2010;68(9):541-546. Available from: https://sid.ir/paper/403891/en

IEEE: Copy

FARIBA YARANDI, ELHAM SHIRALI, ZAHRA EFTEKHAR, and ZAHRA KHAZAEIPOUR, “THE ROLE OF ESTROGEN AND PROGESTERONE RECEPTORS IN RESPONSE RATE TO MEGESTROL ACETATE: CONSERVATIVE TREATMENT OF STAGE IA ENDOMETRIAL ADENOCARCINOMA,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 68, no. 9, pp. 541–546, 2010, [Online]. Available: https://sid.ir/paper/403891/en

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