Cytotoxic effects of Zn oxide nanoparticles against breast cancer T47D cells and NM23 gene expression

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Ghodratpour F.; BAGHBANI ARANI F.; SADAT SHANDIZ SEYED ATAOLLAH

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Journal: Feyz Medical Sciences Journal Year:2019 | Volume:22 | Issue:6 Page(s): 589-594

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Title

Cytotoxic effects of Zn oxide nanoparticles against breast cancer T47D cells and NM23 gene expression

Author(s)

Ghodratpour F. | BAGHBANI ARANI F. | SADAT SHANDIZ SEYED ATAOLLAH | Issue Writer Certificate

Keywords

Breast cancerQ2

ZnONPsQ1

T47DQ1

NM23Q1

Abstract

Background: Breast cancer is the second leading cause of cancer-related death worldwide among women. Nowadays, nanoparticles are interested as anti-cancer factors in studies related to cancer therapy. Therefore, the present study aimed to explore cytotoxic effects of zinc oxide nanoparticles (ZnONPs) and to evaluate NM23 gene expression in T47D Breast cancer cells. Materials and Methods: The cancerous T47D and normal HEK293 cell lines were treated with different concentration of ZnONPs for 24 hours and the cytotoxicity activity of ZnONPs was analyzed by the MTT assay. Then, the NM23 gene expression was evaluated using the real-time PCR method. Results: According to MTT results, the ZnONPs significantly decreased the viability of T47D cells in dose-dependent manner. Also, the results revealed that the mRNA level of NM23 was up-regulated (7. 8-fold) in cells treated with ZnONPs. Conclusion: ZnONPs can destroy cancerous T47D cells compared to normal HEK293 cells. Furthermore, it seems that ZnONPs can modulate metastasis by enhancing the NM23 gene expression level in Breast cancer T47D cells. Thus, ZnONPs can be considered as a promising strategy for the treatment of Breast cancer.

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APA: Copy

Ghodratpour, F., BAGHBANI ARANI, F., & SADAT SHANDIZ, SEYED ATAOLLAH. (2019). Cytotoxic effects of Zn oxide nanoparticles against breast cancer T47D cells and NM23 gene expression. FEYZ, 22(6 ), 589-594. SID. https://sid.ir/paper/40451/en

Vancouver: Copy

Ghodratpour F., BAGHBANI ARANI F., SADAT SHANDIZ SEYED ATAOLLAH. Cytotoxic effects of Zn oxide nanoparticles against breast cancer T47D cells and NM23 gene expression. FEYZ[Internet]. 2019;22(6 ):589-594. Available from: https://sid.ir/paper/40451/en

IEEE: Copy

F. Ghodratpour, F. BAGHBANI ARANI, and SEYED ATAOLLAH SADAT SHANDIZ, “Cytotoxic effects of Zn oxide nanoparticles against breast cancer T47D cells and NM23 gene expression,” FEYZ, vol. 22, no. 6 , pp. 589–594, 2019, [Online]. Available: https://sid.ir/paper/40451/en

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