Effect of Intraperitoneal Administration of Niacin on Postpartum Depression in Adult Female Mice

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Panahizadeh Sima; VALIPOUR CHAHARDAHCHARIC SAEID; RAFIEE RAD MARYAM

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Journal: Jundishapur Scientific Medical Journal Year:2018 | Volume:17 | Issue:4 Page(s): 449-456

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Title

Effect of Intraperitoneal Administration of Niacin on Postpartum Depression in Adult Female Mice

Author(s)

Panahizadeh Sima | VALIPOUR CHAHARDAHCHARIC SAEID | RAFIEE RAD MARYAM | Issue Writer Certificate

Keywords

Postpartum depressionQ2

ProgesteroneQ2

MiceQ2

NiacinQ2

Abstract

Background and Objective: Postpartum depression is a mood disorder that can occur within a year after delivery and influence the mother and even the baby. Because antidepressant medications have numerous side effects, they should be used cautiously especially in nursing mothers. Niacin is involved in the synthesis of serotonin and also no side effects have been reported for its use at low doses. This study aimed to investigate the effect of Niacin on Postpartum depression in female Mice models. Subjects and Methods: In this study seventy two NMARI adult female Mice were used: control, untreated depressed group (receiving Progesterone), four depressed groups were treated with 25, 50, 100 or 200 mg/Kg Niacin for 1 day and three depressed groups were treated for 8 days with 25, 50 or 100 mg/Kg Niacin. The Mice getting 5 mg/Kg of Progesterone for 5 days were intraperitoneally depressed. The control group did not receive any drug or solvent. Depression was assessed using the forced swim test on the eighth day. Results: Niacin prescribed in single dose of 50 (mg/Kg) (P=0. 002) and also at a dose of 50 (mg/Kg) for 8 days (P=0. 000) caused a significant reduction in the immobilization time in the depressed Mice undergone forced swim test, compared to untreated depressed Mice. Conclusion: Prescription of Progesterone promoted immobilization-induced depression in Mice. Niacin reduced the duration of immobility in the forced swimming test.

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APA: Copy

Panahizadeh, Sima, VALIPOUR CHAHARDAHCHARIC, SAEID, & RAFIEE RAD, MARYAM. (2018). Effect of Intraperitoneal Administration of Niacin on Postpartum Depression in Adult Female Mice. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 17(4 ), 449-456. SID. https://sid.ir/paper/404665/en

Vancouver: Copy

Panahizadeh Sima, VALIPOUR CHAHARDAHCHARIC SAEID, RAFIEE RAD MARYAM. Effect of Intraperitoneal Administration of Niacin on Postpartum Depression in Adult Female Mice. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2018;17(4 ):449-456. Available from: https://sid.ir/paper/404665/en

IEEE: Copy

Sima Panahizadeh, SAEID VALIPOUR CHAHARDAHCHARIC, and MARYAM RAFIEE RAD, “Effect of Intraperitoneal Administration of Niacin on Postpartum Depression in Adult Female Mice,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 17, no. 4 , pp. 449–456, 2018, [Online]. Available: https://sid.ir/paper/404665/en

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