THE EFFECT OF DECIDUAL MICROENVIRONMENT ON DENDRITIC CELL FUNCTION IN NORMAL PREGNANCY AND ABORTION

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NAMDAR AHMADABAD H.; SALEHNIA M.; MOAZZENI S.M.

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Paper Information

Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2013 | Volume:16 | Issue:9 (78) Page(s): 0-0

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Title

THE EFFECT OF DECIDUAL MICROENVIRONMENT ON DENDRITIC CELL FUNCTION IN NORMAL PREGNANCY AND ABORTION

Author(s)

NAMDAR AHMADABAD H. | SALEHNIA M. | MOAZZENI S.M. | Issue Writer Certificate

Keywords

ABORTIONQ2

DECIDUAQ2

DENDRITIC CELLSQ2

LYMPHOCYTESQ2

Abstract

Background DECIDUA as maternal-fetal contact surface has a completely different immunological environment from the maternal peripheral blood. The present study aimed to investigate the immunomodulatory activity of molecules secreted by DECIDUAl cells on DENDRITIC CELLS (DCs) function in ABORTION-prone compared with non-ABORTION-prone mice.Materials and Methods: The DECIDUAl cell supernatants (DS) were obtained from ABORTION and non-ABORTION mouse models. Splenic DCs were treated with antigen and DS. Treated DCs were injected into mice palms. After 5 days, draining lymph nodes were removed, cultured in the presence of cognate antigen, and proliferation of lymphocyte cells was measured by 3H-thymidin incorporation.Results: Our results showed that immunosuppressive activity of DS from non-ABORTION-prone mice significantly decrease DENDRITIC CELLS' ability to stimulate LYMPHOCYTES proliferation compared with DS from ABORTION-prone mice (Simulation index (SI) of 4.93±0.34 versus 11.84±0.79).We, also found that DS prepared from non-resorption sites compared with DS from resorption sites in ABORTION-prone mice had increased immunosuppressive activity on DC function (SI of 7.31±1.02 versus 2.67±0.49).Conclusion: We concluded that immunomodulatory activity of molecules secreted within DECIDUAl tissue is different between ABORTION-prone and non-ABORTION-prone mice. We claimed that these molecules, through modulation of DCs function, play crucial role on pregnancy outcome.

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APA: Copy

NAMDAR AHMADABAD, H., SALEHNIA, M., & MOAZZENI, S.M.. (2013). THE EFFECT OF DECIDUAL MICROENVIRONMENT ON DENDRITIC CELL FUNCTION IN NORMAL PREGNANCY AND ABORTION. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 16(9 (78)), 0-0. SID. https://sid.ir/paper/405965/en

Vancouver: Copy

NAMDAR AHMADABAD H., SALEHNIA M., MOAZZENI S.M.. THE EFFECT OF DECIDUAL MICROENVIRONMENT ON DENDRITIC CELL FUNCTION IN NORMAL PREGNANCY AND ABORTION. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2013;16(9 (78)):0-0. Available from: https://sid.ir/paper/405965/en

IEEE: Copy

H. NAMDAR AHMADABAD, M. SALEHNIA, and S.M. MOAZZENI, “THE EFFECT OF DECIDUAL MICROENVIRONMENT ON DENDRITIC CELL FUNCTION IN NORMAL PREGNANCY AND ABORTION,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 16, no. 9 (78), pp. 0–0, 2013, [Online]. Available: https://sid.ir/paper/405965/en

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