INDUCTION OF PARKINSON’S DISEASE MODEL IN RAT BY ROTENONE

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RAHIMMI ARMAN; KHOSROBAKHSH FARNOOSH; IZADPANAH ESMAIL; HASSANZADEH KAMBIZ

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2014 | Volume:32 | Issue:296 Page(s): 0-0

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Title

INDUCTION OF PARKINSON’S DISEASE MODEL IN RAT BY ROTENONE

Author(s)

RAHIMMI ARMAN | KHOSROBAKHSH FARNOOSH | IZADPANAH ESMAIL | HASSANZADEH KAMBIZ | Issue Writer Certificate

Keywords

PARKINSON’S DISEASEQ2

ROTENONEQ2

ROTAROD TESTQ2

Abstract

Background: Many efforts have been made to find a proper animal model for PARKINSON’S DISEASE, in order to improve our knowledge about this disorder and find therapeutic approaches. Generally the reproducibility of experiments in laboratory animals is accompanied by some troubles. Therefore the validity of model is certified by certain behavioral tests. Thus the present study was aimed to find an accurate and reproducible rat model of PARKINSON’S DISEASE by ROTENONE.Methods: Male Wistar rats weighting 400±50 g (10-12 months) received several doses of ROTENONE (1, 2, 3 mg/kg) or its vehicle subcutaneously every 48 hours. Three behavioral tests (rotarod, rearing and bar) were run in order to check the development of model.Findings: Results indicated that ROTENONE (2 mg/kg/48h) was an efficient dose beside its low mortality. It was found that the latency time of ROTAROD TEST and movement skills in rearing test decreased significantly in ROTENONE (2 mg/kg/48h) treated animals (p<0.05). In addition, the results of bar test showed the augmentation of catalepsy in ROTENONE group compared to vehicle treated animals (p<0.05). In addition the statistical correlation between behavioral tests justified the development of movement disorders in the model.Conclusion: According to the results, it was concluded that ROTENONE (2 mg/kg/48h) was the best approach with reproducible capacity for induction of PARKINSON’S DISEASE model.

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APA: Copy

RAHIMMI, ARMAN, KHOSROBAKHSH, FARNOOSH, IZADPANAH, ESMAIL, & HASSANZADEH, KAMBIZ. (2014). INDUCTION OF PARKINSON’S DISEASE MODEL IN RAT BY ROTENONE. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 32(296), 0-0. SID. https://sid.ir/paper/405973/en

Vancouver: Copy

RAHIMMI ARMAN, KHOSROBAKHSH FARNOOSH, IZADPANAH ESMAIL, HASSANZADEH KAMBIZ. INDUCTION OF PARKINSON’S DISEASE MODEL IN RAT BY ROTENONE. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2014;32(296):0-0. Available from: https://sid.ir/paper/405973/en

IEEE: Copy

ARMAN RAHIMMI, FARNOOSH KHOSROBAKHSH, ESMAIL IZADPANAH, and KAMBIZ HASSANZADEH, “INDUCTION OF PARKINSON’S DISEASE MODEL IN RAT BY ROTENONE,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 32, no. 296, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/405973/en

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