Effect of Morphine on Passive Avoidance Memory in Cholestatic Rats

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Poureidi Mahsa; Heydarnia Kalati Zinat; Abtahi Evary Seyed Hosein; Fani Masoumeh; MOGHIMIAN MARYAM

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Journal: Journal of Mazandaran University of Medical Sciences Year:2020 | Volume:30 | Issue:186 Page(s): 13-23

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Title

Effect of Morphine on Passive Avoidance Memory in Cholestatic Rats

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Keywords

morphineQ2

passive avoidance memoryQ2

cholestasisQ1

Abstract

Background and purpose: morphine as an opioid compound has different and sometimes conflicting effects on memory and learning process. Bile duct ligation causes cholestasis, which disrupts liver function. It is known that opioid systems are involved in cholestasis. The aim of this study was to investigate the possible effect of morphine on the memory of cholestatic rats. Materials and methods: In this experimental study, the cholestatic model in male Wistar rats (weighing 200-250 g) was induced by bile duct ligation (BDL). The animals were injected with morphine (4 and 6 mg/kg, ip), naloxone (0. 6 and 0. 8 mg/kg, ip), and morphine and naloxone in different groups. passive avoidance memory was evaluated on day 7 after BDL by shuttle box test. Data were analyzed by PRISM software and ANOVA. Results: Naloxone (0. 6 and 0. 8 mg/kg), 30 min before the test, did not show significant changes in the memory of the cholestatic rats compared to the BDL group, whereas, morphine (4 and 6 mg/kg) showed significant increase in step-through latency (P<0. 05). Also, naloxone (0. 6 mg/kg, ip) 15 minutes before injection of morphine (6 mg/kg) showed a significant increase in acquired memory on day 7 after BDL (P<0. 0001). Conclusion: According to findings, morphine had a protective effect on memory impairment induced by cholestasis.

Cites

The Role of Gender on Memory in Cholestatic rats Gender, Memory and Cholestasis

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APA: Copy

Poureidi, Mahsa, Heydarnia Kalati, Zinat, Abtahi Evary, Seyed Hosein, Fani, Masoumeh, & MOGHIMIAN, MARYAM. (2020). Effect of Morphine on Passive Avoidance Memory in Cholestatic Rats. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 30(186 ), 13-23. SID. https://sid.ir/paper/406728/en

Vancouver: Copy

Poureidi Mahsa, Heydarnia Kalati Zinat, Abtahi Evary Seyed Hosein, Fani Masoumeh, MOGHIMIAN MARYAM. Effect of Morphine on Passive Avoidance Memory in Cholestatic Rats. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;30(186 ):13-23. Available from: https://sid.ir/paper/406728/en

IEEE: Copy

Mahsa Poureidi, Zinat Heydarnia Kalati, Seyed Hosein Abtahi Evary, Masoumeh Fani, and MARYAM MOGHIMIAN, “Effect of Morphine on Passive Avoidance Memory in Cholestatic Rats,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 30, no. 186 , pp. 13–23, 2020, [Online]. Available: https://sid.ir/paper/406728/en

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