The Role of Middle Septal Ghrelin Receptors in the Effects of Morphine on Memory Consolidation in Passive Avoidance Learning

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Dastjanifarahani S.; DARBANDI N.; NAZARI SERENJEH F.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Ilam University of Medical Sciences Year:2020 | Volume:28 | Issue:3 Page(s): 1-10

Download Full-Text

Persian Verion

View:

357

Download:

Cites:

Information Journal Paper

Title

The Role of Middle Septal Ghrelin Receptors in the Effects of Morphine on Memory Consolidation in Passive Avoidance Learning

Author(s)

Dastjanifarahani S. | DARBANDI N. | NAZARI SERENJEH F. | Issue Writer Certificate

Keywords

GhrelinQ1

Inhibitory avoidance learningQ1

Medial septumQ1

MorphineQ2

Male ratQ1

Abstract

Introduction: Evidence indicates that Morphine impairs memory process. Ghrelin hormone has been linked to learning and memory processes and modulates reward properties of addictive drugs. In this study we examined the role of middle septal Ghrelin receptors in the effects of Morphine on memory consolidation in passive avoidance learning. Materials & Methods: In this experimental study, 91 male Wistar rats were randomly divided into 13 (n=7) groups: saline (1ml/kg), Morphine (0. 5-7. 5 mg/kg), Ghrelin (0-1 nmol/μ l) plus Morphine (7. 5 mg/kg) or saline (1ml/kg). In Ghrelin treated groups animals received intra-Medial septum injection of Ghrelin immediately after training and 5 min later saline or Morphine was injected subcutaneously. Testing phase was done 24 h after training. Data were analyzed using ANOVA analysis followed by Tukey multiple comparison test. Ethics code: IR. ARAKMU. REC. 1397. 215 Findings: Post-training administration of Morphine reduced step-through latency and increased Total dark chamber compared with saline group (p< 0. 001). Intra-Medial septum injection of Ghrelin inhibited Morphine-induced amnesia (p< 0. 001). Administration of Ghrelin alone had no significant effect on memory retrieval (P > 0. 05). Disscution & Conclusions: Ghrelin is able to prevent the deleterious effects of Morphine on memory and learning in the inhibitory avoidance model and the medial septal region may be involved in this effect.

Cites

No record.

References

Cite

APA: Copy

Dastjanifarahani, S., DARBANDI, N., & NAZARI SERENJEH, F.. (2020). The Role of Middle Septal Ghrelin Receptors in the Effects of Morphine on Memory Consolidation in Passive Avoidance Learning. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 28(3 ), 1-10. SID. https://sid.ir/paper/381268/en

Vancouver: Copy

Dastjanifarahani S., DARBANDI N., NAZARI SERENJEH F.. The Role of Middle Septal Ghrelin Receptors in the Effects of Morphine on Memory Consolidation in Passive Avoidance Learning. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;28(3 ):1-10. Available from: https://sid.ir/paper/381268/en

IEEE: Copy

S. Dastjanifarahani, N. DARBANDI, and F. NAZARI SERENJEH, “The Role of Middle Septal Ghrelin Receptors in the Effects of Morphine on Memory Consolidation in Passive Avoidance Learning,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 3 , pp. 1–10, 2020, [Online]. Available: https://sid.ir/paper/381268/en

Related Journal Papers