Influence of different phonological stage of Achillea pachycephala Rech. f. on albumin glycation inhibition, an in vitro study

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AFSHARI M.; RAHIMMALEK M.; MIROLIAEI M.

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Journal: Journal of Molecular and Cellular Researches Year:2019 | Volume:32 | Issue:3 Page(s): 409-422

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Title

Influence of different phonological stage of Achillea pachycephala Rech. f. on albumin glycation inhibition, an in vitro study

Author(s)

AFSHARI M. | RAHIMMALEK M. | MIROLIAEI M. | Issue Writer Certificate

Keywords

antioxidant activityQ1

antiglycationQ1

AchilleaQ2

phenological stagesQ1

Abstract

From biomedicine point of view, the application of medicinal plants to prevent and treat diabetes via intervention in biomolecule degradation mechanisms, is an important issue. Achillea L. belongs to Asteraceae family and have traditional properties with different applications in folk medicine. A. pachycephala is one of the valuable species of Achillea which has been considered as a rich source of antioxidants. The present study aimed to investigate the effect of various phenological stages including five leaves appearance, sprouting, 50% and 100% flowering on antiglycative and antioxidant activity of A. pachycephala flowers extract. antioxidant activity were evaluated based on 1, 1-diphenyl 2-picrylhydrazyl (DPPH) and reducing power (FTC) methods. The inhibitory effect of the extracts was determined in albumin glycation model using Congo red binding and brown staining assays. The results showed that the extracts collected at 50% flowering stage had the highest antiglycative potential, the highest amounts of total phenols, total flavonoids and antioxidant activities. Besides, a direct correlation between antioxidant and anti-glycative activity was suggested. Most likely, A. pachycephala prevents albumin glycation originating from its strong antioxidant properties, therefore it can be considered as a good candidate for reducing complications of diabetes.

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APA: Copy

AFSHARI, M., RAHIMMALEK, M., & MIROLIAEI, M.. (2019). Influence of different phonological stage of Achillea pachycephala Rech. f. on albumin glycation inhibition, an in vitro study. JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY), 32(3 ), 409-422. SID. https://sid.ir/paper/407113/en

Vancouver: Copy

AFSHARI M., RAHIMMALEK M., MIROLIAEI M.. Influence of different phonological stage of Achillea pachycephala Rech. f. on albumin glycation inhibition, an in vitro study. JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY)[Internet]. 2019;32(3 ):409-422. Available from: https://sid.ir/paper/407113/en

IEEE: Copy

M. AFSHARI, M. RAHIMMALEK, and M. MIROLIAEI, “Influence of different phonological stage of Achillea pachycephala Rech. f. on albumin glycation inhibition, an in vitro study,” JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY), vol. 32, no. 3 , pp. 409–422, 2019, [Online]. Available: https://sid.ir/paper/407113/en

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