ENDOTOXIN RELEASE FROM SALMONELLA TIPHI BY ANTIBIOTICS

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SHAJARI GH.R.; TABARAEI BAHMAN; BEHZADIANNEZHAD GH.

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Journal: Feyz Medical Sciences Journal Year:2000 | Volume:4 | Issue:13 Page(s): 15-21

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Title

ENDOTOXIN RELEASE FROM SALMONELLA TIPHI BY ANTIBIOTICS

Author(s)

SHAJARI GH.R. | TABARAEI BAHMAN | BEHZADIANNEZHAD GH. | Issue Writer Certificate

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Abstract

History and Objectives: Due to high prevalence of typhoid fever and its antibiotic treatment which may lead to the release of high levels of endotoxins and subsequent side effects, determination of the level of antibiotic induced endotoxin release is essential. With this in mind, the present study is carried out at Pasteur Institute of Iran in 1995.Material and Methods: A descriptive study was conducted to determine the MIC and MBC on antibiotics such as ampicilin, chloaramphenicol and co-trimoxizole, used for the treatment of typhoid fever. Cell culture and their maintanance, preparation of antibiotic solutions, etermination of MIC and MBC on each bacteria and determination of endotoxin release were carried out using standard methods by thriple measurements (pg/ml). Analytical variance was used as a statistical method.Results: MIC and MBC for ampicillin was lower compared to other antibiotics (MIC=MBC=1.25ug/ml). Level of endotoxin release from ampicilin, chloramphenicol and co-timoxizole was 113±8, 87±2.5 and 134±11.6 pg/mL respectively (p<0.05). Conclusions: Chloramphenicol produces less endotoxin compared to other antibiotic tested. Similar in vivo experiments are suggested.

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APA: Copy

SHAJARI, GH.R., TABARAEI, BAHMAN, & BEHZADIANNEZHAD, GH.. (2000). ENDOTOXIN RELEASE FROM SALMONELLA TIPHI BY ANTIBIOTICS. FEYZ, 4(13), 15-21. SID. https://sid.ir/paper/40712/en

Vancouver: Copy

SHAJARI GH.R., TABARAEI BAHMAN, BEHZADIANNEZHAD GH.. ENDOTOXIN RELEASE FROM SALMONELLA TIPHI BY ANTIBIOTICS. FEYZ[Internet]. 2000;4(13):15-21. Available from: https://sid.ir/paper/40712/en

IEEE: Copy

GH.R. SHAJARI, BAHMAN TABARAEI, and GH. BEHZADIANNEZHAD, “ENDOTOXIN RELEASE FROM SALMONELLA TIPHI BY ANTIBIOTICS,” FEYZ, vol. 4, no. 13, pp. 15–21, 2000, [Online]. Available: https://sid.ir/paper/40712/en

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