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Title

THE EFFECT OF HONEY BEE VENOM ON LEVELS OF LIPIDS AND ANTI-MULLERIAN HORMONE IN A RAT WITH POLYCYSTIC OVARIAN SYNDROME

Pages

  239-246

Abstract

 Background: POLYCYSTIC OVARIAN SYNDROME (PCOS) is an inflammatory disease. HONEY BEE VENOM (HBV) contains a variety of enzymes and biologically active amines that its analgesic and anti-inflammatory effects have been established on PCOS. This study aimed to examine the effect of HBV on changes in ANTI-MULLERIAN HORMONE (AMH), triglyceride and LDL levels in rats with PCOS.Materials and Methods: This experimental study was conducted on 63 female Wistar rats. PCOS was induced by a single-stage subcutaneous injection of ESTRADIOL VALERATE (2 mg⁄100grBW). After 60 days of injection, HBV dissolved in PBS (0.2 mg/kg) was injected intraperitoneally for ten days. Then the rats were sacrificed and the ovarian tissues in the control, PCOS and HBV-treated PCOS groups were collected for histological study. Finally, the blood serum was isolated to measure the changes in lipid and AMH levels using ELISA method.Results: Histological studies showed a significant reduction in corpus luteum (CL) diameter in PCOS group compared with the control group; an increase in CL in the HBV-treated group compared with the PCOS group. Blood triglycerides and LDL levels in PCOS group were increased compared with the control group, while it was decreased in the HBV-treated group. Moreover, AMH increased in the PCOS group compared with the control one, but it was decreased in the HBV group.Conclusion: HBV has a beneficial effect on PCOS probably through the expression of AMH factor and the reduction of triglycerides and LDL levels.

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References

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APA: Copy

POUYANMANESH, F., NABIUNI, M., NASRI, S., NAZARI, Z., & KARIMZADEH, L.. (2013). THE EFFECT OF HONEY BEE VENOM ON LEVELS OF LIPIDS AND ANTI-MULLERIAN HORMONE IN A RAT WITH POLYCYSTIC OVARIAN SYNDROME. FEYZ, 17(3), 239-246. SID. https://sid.ir/paper/40734/en

Vancouver: Copy

POUYANMANESH F., NABIUNI M., NASRI S., NAZARI Z., KARIMZADEH L.. THE EFFECT OF HONEY BEE VENOM ON LEVELS OF LIPIDS AND ANTI-MULLERIAN HORMONE IN A RAT WITH POLYCYSTIC OVARIAN SYNDROME. FEYZ[Internet]. 2013;17(3):239-246. Available from: https://sid.ir/paper/40734/en

IEEE: Copy

F. POUYANMANESH, M. NABIUNI, S. NASRI, Z. NAZARI, and L. KARIMZADEH, “THE EFFECT OF HONEY BEE VENOM ON LEVELS OF LIPIDS AND ANTI-MULLERIAN HORMONE IN A RAT WITH POLYCYSTIC OVARIAN SYNDROME,” FEYZ, vol. 17, no. 3, pp. 239–246, 2013, [Online]. Available: https://sid.ir/paper/40734/en

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