THE EFFECTIVENESS OF NERVE LIGATIONON MORPHINE, CCK AGONIST OR ANTAGONIST-INDUCED ANTINOCICEPTION BY HOT-PLATETEST IN MICE

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MESDAGHINIA A.; REZAYAT M.

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Journal: Feyz Medical Sciences Journal Year:2000 | Volume:4 | Issue:15 Page(s): 1-10

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Title

THE EFFECTIVENESS OF NERVE LIGATIONON MORPHINE, CCK AGONIST OR ANTAGONIST-INDUCED ANTINOCICEPTION BY HOT-PLATETEST IN MICE

Author(s)

MESDAGHINIA A. | REZAYAT M. | Issue Writer Certificate

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Abstract

History and Objectives: Due to descrepencies on the role of cholecystokinin receptors in pain, and Oil the role of surgical processes and nerve ligation as a pain inducer and hyperalegesic agent, the present experimental study was carried. Materials and methods: An experimental study was performed on groups of nine mice. The unilateral nerve ligation was made on the light hind limb, according to the Seltzer's method. The pain sensitivity was measured by the hot-plate test based on Eddy and Leimbach's method. Antinociception was measured in a 60min period of time (15, 30, 45, 60min) after injection. Control group in all of the experiments were received vehicle or saline solution. Experimental group were compared with the control group.Results: Different doses of morphine (3, 6 and 9mg/Kg) induced a dose dependent antinociception in the intact and nerve ligated animals but nerve ligation did not decrease caerulein response. In another experiment, carulein, proglumide and the combination of two rugs induced antinociception but there was no interaction between the two drugs. Conclusions: CCK agonists or their combination with morphine can be used for the treatment of neuropathic pain. The mechanism of action of CCK agonist has not been elucidated and further research is needed to unravel its action.

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APA: Copy

MESDAGHINIA, A., & REZAYAT, M.. (2000). THE EFFECTIVENESS OF NERVE LIGATIONON MORPHINE, CCK AGONIST OR ANTAGONIST-INDUCED ANTINOCICEPTION BY HOT-PLATETEST IN MICE. FEYZ, 4(15), 1-10. SID. https://sid.ir/paper/40892/en

Vancouver: Copy

MESDAGHINIA A., REZAYAT M.. THE EFFECTIVENESS OF NERVE LIGATIONON MORPHINE, CCK AGONIST OR ANTAGONIST-INDUCED ANTINOCICEPTION BY HOT-PLATETEST IN MICE. FEYZ[Internet]. 2000;4(15):1-10. Available from: https://sid.ir/paper/40892/en

IEEE: Copy

A. MESDAGHINIA, and M. REZAYAT, “THE EFFECTIVENESS OF NERVE LIGATIONON MORPHINE, CCK AGONIST OR ANTAGONIST-INDUCED ANTINOCICEPTION BY HOT-PLATETEST IN MICE,” FEYZ, vol. 4, no. 15, pp. 1–10, 2000, [Online]. Available: https://sid.ir/paper/40892/en

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