ANTINOCICEPTIVE EFFECT OF GABA ERGIC AGENTS AND THEIR EFFECT ON MORPHINE TOLERANCE IN SCIATIC NERVE LIGATION-INDUCED PAIN

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MAHMOUDI M.; ZARINDAST M.R.

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Journal: Physiology and Pharmacology Year:2002 | Volume:5 | Issue:2 Page(s): 109-120

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Title

ANTINOCICEPTIVE EFFECT OF GABA ERGIC AGENTS AND THEIR EFFECT ON MORPHINE TOLERANCE IN SCIATIC NERVE LIGATION-INDUCED PAIN

Author(s)

MAHMOUDI M. | ZARINDAST M.R. | Issue Writer Certificate

Keywords

ANTINOCICEPTIONQ4

MUSCIMOLQ3

BACLOFENQ4

SCIATIC NERVE LIGATIONQ4

MICEQ3

Abstract

In the present study, the effect of GABA (γ-aminobutyric acid) receptor agonists and antagonists on pain induced by SCIATIC NERVE LIGATION was investigated in MICE. Antinociceptive effect of morphine or GABA receptor agonists was examined 14days after unilateral ligation of sciatic nerve by hot-plate test. Intraperitoneal injection of different doses of morphine (3, 6, and 9 mg/Kg), MUSCIMOL (0.5, 1, and 2 mg/Kg) or BACLOFEN (I, 2.5, and 5 mg/Kg) induced a dose-dependent ANTINOCICEPTION in both intact and nerve-ligated MICE. In this respect, the response for morphine but not that of MUSCIMOL or BACLOFEN was significantly less in nerve-ligated MICE than that induced in intact animals. The responses induced by MUSCIMOL or BACLOFEN in nerve-ligated animals were reduced by bicuculline and CGP35348 respectively. However, morphine (3 mg/Kg) in combination with different doses of MUSCIMOL or BACLOFEN tends to enhance the antinociceptive effect of morphine in nerve-ligated MICE. Subcutaneous injection of the opioid receptor antagonist naloxone (0.5, 1, and 2 mg/Kg; s.c.) reduced the response induced by MUSCIMOL or BACLOFEN in nerve-ligated animals. It can be concluded that reducing effect of naloxone on antinociceptive effect of MUSCIMOL and BACLOFEN is mediated through GABAA and GABAB receptors respectively and, at least part of the ANTINOCICEPTION induced by GABAA receptor may be affected through opioid receptor mechanism.

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APA: Copy

MAHMOUDI, M., & ZARINDAST, M.R.. (2002). ANTINOCICEPTIVE EFFECT OF GABA ERGIC AGENTS AND THEIR EFFECT ON MORPHINE TOLERANCE IN SCIATIC NERVE LIGATION-INDUCED PAIN. PHYSIOLOGY AND PHARMACOLOGY, 5(2), 109-120. SID. https://sid.ir/paper/74976/en

Vancouver: Copy

MAHMOUDI M., ZARINDAST M.R.. ANTINOCICEPTIVE EFFECT OF GABA ERGIC AGENTS AND THEIR EFFECT ON MORPHINE TOLERANCE IN SCIATIC NERVE LIGATION-INDUCED PAIN. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2002;5(2):109-120. Available from: https://sid.ir/paper/74976/en

IEEE: Copy

M. MAHMOUDI, and M.R. ZARINDAST, “ANTINOCICEPTIVE EFFECT OF GABA ERGIC AGENTS AND THEIR EFFECT ON MORPHINE TOLERANCE IN SCIATIC NERVE LIGATION-INDUCED PAIN,” PHYSIOLOGY AND PHARMACOLOGY, vol. 5, no. 2, pp. 109–120, 2002, [Online]. Available: https://sid.ir/paper/74976/en

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