Comparison of the Concentration of Inflammatory Cytokines TNF-α and Interleukin-1β in Saliva of Healthy Subjects and Patients with Gingivitis and Chronic Periodontitis

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Malek Sajad; ESFAHANIAN VAHID; Torabzadeh Majid

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Mashhad Dental School Year:2020 | Volume:44 | Issue:2 Page(s): 166-173

Download Full-Text

Persian Verion

View:

283

Download:

Cites:

Information Journal Paper

Title

Comparison of the Concentration of Inflammatory Cytokines TNF-α and Interleukin-1β in Saliva of Healthy Subjects and Patients with Gingivitis and Chronic Periodontitis

Author(s)

Malek Sajad | ESFAHANIAN VAHID | Torabzadeh Majid | Issue Writer Certificate

Keywords

GingivitisQ1

Interleukin-1 betaQ1

PeriodontitisQ3

SalivaQ3

TNF-αQ2

Abstract

Introduction: Periodontitis is an inflammatory disease of the supporting tissues of the tooth that is caused by microorganisms. Nowadays, the role of inflammatory mediators has been shown in innate and acquired immunity in Periodontitis, and some of them play important roles in the pathogenesis of Periodontitis. This study aimed to determine and compare the concentration of inflammatory cytokines TNF-α and Interleukin-1 beta in the Saliva of healthy subjects and patients with Gingivitis and chronic Periodontitis. Materials and Methods: This study was conducted based on a descriptive-analytical design. Unstimulated Saliva samples were collected from 45 subjects, including healthy individuals (n=15), and the patients with Periodontitis (n=15) and Gingivitis (n=15). Subsequently, the level of TNF-α and Interleukin-1 beta were determined by enzyme-linked immunosorbent assay reader. The data were analyzed in SPSS software (version 11) through ANOVA, Tukey's post hoc tests, and Pearson correlation coefficient. Results: There was a significant difference among the three groups regarding the mean concentration of Interleukin-1 beta and TNF-α (P<0. 001). Healthy subjects exhibited significantly lower concentration of TNF-α , compared to those with Gingivitis. Moreover, the patients with Gingivitis showed lower concentration of TNF-α , compared to the group with chronic Periodontitis (P<0. 001). Regarding the concentration of Interleukin-1 beta, healthy subjects exhibited significantly lower concentration in this regard, compared to those with chronic Periodontitis (P<0. 001). Furthermore, the group with chronic Periodontitis obtained lower level of this value, compared to the group with Gingivitis (P<0. 001). Additionally, there was a direct and significant relationship between IL-1 and TNF-α concentration in patients with Gingivitis (P=0. 03 and r=0. 354) and all the subjects (P<0. 001 and r=0. 556). Conclusion: The levels of TNF-α and Interleukin-1 beta in Saliva increased during periodontal disease, compared to healthy conditions.

Cites

No record.

References

Cite

APA: Copy

Malek, Sajad, ESFAHANIAN, VAHID, & Torabzadeh, Majid. (2020). Comparison of the Concentration of Inflammatory Cytokines TNF-α and Interleukin-1β in Saliva of Healthy Subjects and Patients with Gingivitis and Chronic Periodontitis. JOURNAL OF MASHHAD DENTAL SCHOOL, 44(2 ), 166-173. SID. https://sid.ir/paper/408953/en

Vancouver: Copy

Malek Sajad, ESFAHANIAN VAHID, Torabzadeh Majid. Comparison of the Concentration of Inflammatory Cytokines TNF-α and Interleukin-1β in Saliva of Healthy Subjects and Patients with Gingivitis and Chronic Periodontitis. JOURNAL OF MASHHAD DENTAL SCHOOL[Internet]. 2020;44(2 ):166-173. Available from: https://sid.ir/paper/408953/en

IEEE: Copy

Sajad Malek, VAHID ESFAHANIAN, and Majid Torabzadeh, “Comparison of the Concentration of Inflammatory Cytokines TNF-α and Interleukin-1β in Saliva of Healthy Subjects and Patients with Gingivitis and Chronic Periodontitis,” JOURNAL OF MASHHAD DENTAL SCHOOL, vol. 44, no. 2 , pp. 166–173, 2020, [Online]. Available: https://sid.ir/paper/408953/en

Related Journal Papers