DETERMINATION OF HEPATITIS B SURFACE ANTIBODY AND GAMMA INTERFERON RESPONSIVENESS IN VACCINATED PERSONNEL REFFERED TO A HEALTH NETWORK IN DASHTE-E AZADEGAN (KHOZESTAN PROVINCE)

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HEIDARI S.; REZATOFIGHI S.E.; ROAYAEI ARDAKANI M.; AKHOND M.R.

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Journal: Feyz Medical Sciences Journal Year:2016 | Volume:20 | Issue:3 Page(s): 274-281

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Title

DETERMINATION OF HEPATITIS B SURFACE ANTIBODY AND GAMMA INTERFERON RESPONSIVENESS IN VACCINATED PERSONNEL REFFERED TO A HEALTH NETWORK IN DASHTE-E AZADEGAN (KHOZESTAN PROVINCE)

Author(s)

HEIDARI S. | REZATOFIGHI S.E. | ROAYAEI ARDAKANI M. | AKHOND M.R. | Issue Writer Certificate

Keywords

HEPATITIS BQ3

VACCINATIONQ3

GAMMA INTERFERONQ2

ANTIBODYQ3

PERSONNELQ3

Abstract

Background: Among the preventing measures for HEPATITIS B is VACCINATION against the virus. This study aimed to determine the ANTIBODY level against the HEPATITIS B surface antigen (anti-HBs) and its relation to interferon gamma (IFN-g) level among the vaccinated staffs and also the reasons for the lack of response in such persons.Materials and Methods: This cross-sectional study was done on vaccinated staff (n=130) referred to Shahid Chamran Hospital. Using ELISA the samples were studied for anti-HBsAb and INF-g level. Then, the relationship between ANTIBODY level and some indexes (e.g. sex, age, BMI, number of vaccine doses, time past after the last dose and INF-g level) was considered.Results: Among the studied participants, 68.5% and 31.5% had a perfect and failure of immunity response (>10 IU/ml and<10 IU/ml, respectively). There was a direct relationship between the INF-g and anti-HBs titration (R=0.635). In addition, there was a significant relationship (P<0.05) between anti-HBs titer and some indexes (e.g. BMI, the number of doses and the time interval since the last dose of vaccine); however, no significant relationship was observed between the sex and age on one hand and ANTIBODY titration on the other hand.Conclusion: Failure in INF-g production against the virus can have a role in immunity response. Hence, measuring the anti-HBs level following the VACCINATION and also 5 years after are suggested for high risk cases; then, upon which a decision can be made on the reminder dosage.

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APA: Copy

HEIDARI, S., REZATOFIGHI, S.E., ROAYAEI ARDAKANI, M., & AKHOND, M.R.. (2016). DETERMINATION OF HEPATITIS B SURFACE ANTIBODY AND GAMMA INTERFERON RESPONSIVENESS IN VACCINATED PERSONNEL REFFERED TO A HEALTH NETWORK IN DASHTE-E AZADEGAN (KHOZESTAN PROVINCE). FEYZ, 20(3 ), 274-281. SID. https://sid.ir/paper/40962/en

Vancouver: Copy

HEIDARI S., REZATOFIGHI S.E., ROAYAEI ARDAKANI M., AKHOND M.R.. DETERMINATION OF HEPATITIS B SURFACE ANTIBODY AND GAMMA INTERFERON RESPONSIVENESS IN VACCINATED PERSONNEL REFFERED TO A HEALTH NETWORK IN DASHTE-E AZADEGAN (KHOZESTAN PROVINCE). FEYZ[Internet]. 2016;20(3 ):274-281. Available from: https://sid.ir/paper/40962/en

IEEE: Copy

S. HEIDARI, S.E. REZATOFIGHI, M. ROAYAEI ARDAKANI, and M.R. AKHOND, “DETERMINATION OF HEPATITIS B SURFACE ANTIBODY AND GAMMA INTERFERON RESPONSIVENESS IN VACCINATED PERSONNEL REFFERED TO A HEALTH NETWORK IN DASHTE-E AZADEGAN (KHOZESTAN PROVINCE),” FEYZ, vol. 20, no. 3 , pp. 274–281, 2016, [Online]. Available: https://sid.ir/paper/40962/en

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