INVESTIGATION OF HLA.DRB, DRA1, DQB1, ALLELES AND HAPLOTYPES FREQUENCY IN IRANIAN PATIENTS WITH ACUTE MYELOGENOUS LEUKEMIA BY PCR.SSP METHOD

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NOUR ASHRAF ALDIN S.M.; AMIRZARGAR ALI AKBAR; ALI MOGHADAM K.; KHOSRAVI F.; GHAVAMZADEH ARDESHIR; NIKBIN B.

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Journal: Journal of Medical Council of Iran Year:2006 | Volume:23 | Issue:4 Page(s): 375-382

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Title

INVESTIGATION OF HLA.DRB, DRA1, DQB1, ALLELES AND HAPLOTYPES FREQUENCY IN IRANIAN PATIENTS WITH ACUTE MYELOGENOUS LEUKEMIA BY PCR.SSP METHOD

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Keywords

HLA (HUMAN LEUKOCYTE ANTIGEN)Q4

AML (ACUTE MYELOGENOUS LEUKEMIA)Q2

PCR (POLYMERASE CHAIN REACTION)Q2

Abstract

Myelogenous leukemia is the most important hematopoietic system disease in today's world. Previous studies have indicated that Immunogenetic factors play important role in the production of myelogenous leukemia. This study has attempted to recognize the immunogenetical factors in predisposition or prevention of acute myelogenous leukemia.In the present case-control analytic study. Sixty (60) acute myelogenous leukemia patient's HLA class II alleles (DRB, DQA1 and DQB1) are detected and compared with eighty (80) healthy subjects by PCR-ssp method for the first time in Iran. In acute myelogenous leukemia patients, the frequencies of alle1es DRB1 *16 and DQB1 *03011 were significantly higher than in healthy subjects. In contrast, frequencies of alleles DRB1*07, DRB4*01 (DR53), DQB1*0604, DQB1*05031, DQB1*03032 and DQA1*0201 were significantly lower. And frequencies of haplotypes HLA-DRB1*11, DQB1 *03011, DQA1 *0505 and HLADRB1*16, DQB1 *0505, DQA1 *01021 were significantly higher, by contrast, frequency of haplotype HLA-DRB1*07, DQB1*0201, DQA1 *0201 was significantly lower in these patients in comparison with healthy subjects.The HLA system appears to have an important genetic influence in predisposition or prevention of acute myelogenous leukemia.

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APA: Copy

NOUR ASHRAF ALDIN, S.M., AMIRZARGAR, ALI AKBAR, ALI MOGHADAM, K., KHOSRAVI, F., GHAVAMZADEH, ARDESHIR, & NIKBIN, B.. (2006). INVESTIGATION OF HLA.DRB, DRA1, DQB1, ALLELES AND HAPLOTYPES FREQUENCY IN IRANIAN PATIENTS WITH ACUTE MYELOGENOUS LEUKEMIA BY PCR.SSP METHOD. JOURNAL OF MEDICAL COUNCIL OF I.R.I., 23(4), 375-382. SID. https://sid.ir/paper/41000/en

Vancouver: Copy

NOUR ASHRAF ALDIN S.M., AMIRZARGAR ALI AKBAR, ALI MOGHADAM K., KHOSRAVI F., GHAVAMZADEH ARDESHIR, NIKBIN B.. INVESTIGATION OF HLA.DRB, DRA1, DQB1, ALLELES AND HAPLOTYPES FREQUENCY IN IRANIAN PATIENTS WITH ACUTE MYELOGENOUS LEUKEMIA BY PCR.SSP METHOD. JOURNAL OF MEDICAL COUNCIL OF I.R.I.[Internet]. 2006;23(4):375-382. Available from: https://sid.ir/paper/41000/en

IEEE: Copy

S.M. NOUR ASHRAF ALDIN, ALI AKBAR AMIRZARGAR, K. ALI MOGHADAM, F. KHOSRAVI, ARDESHIR GHAVAMZADEH, and B. NIKBIN, “INVESTIGATION OF HLA.DRB, DRA1, DQB1, ALLELES AND HAPLOTYPES FREQUENCY IN IRANIAN PATIENTS WITH ACUTE MYELOGENOUS LEUKEMIA BY PCR.SSP METHOD,” JOURNAL OF MEDICAL COUNCIL OF I.R.I., vol. 23, no. 4, pp. 375–382, 2006, [Online]. Available: https://sid.ir/paper/41000/en

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