SERUM LIPID PEROXIDATION AND TOTAL ANTIOXIDANT STATUS IN HEMODIALYSIS AND CONTINUOUS AMBULATORY PERITONEAL DIALYSIS PATIENTS

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SEYEDREZAZADEH E.; ARDALAN M.R.; POURMOGHADAM M.

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Journal: Journal of Medical Council of Iran Year:2008 | Volume:25 | Issue:4 Page(s): 497-504

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Title

SERUM LIPID PEROXIDATION AND TOTAL ANTIOXIDANT STATUS IN HEMODIALYSIS AND CONTINUOUS AMBULATORY PERITONEAL DIALYSIS PATIENTS

Author(s)

SEYEDREZAZADEH E. | ARDALAN M.R. | POURMOGHADAM M. | Issue Writer Certificate

Keywords

HEMODIALYSISQ3

PERITONEAL DIALYSISQ2

OXIDATIVE STRESSQ2

TOTAL ANTIOXIDANT STATUSQ3

Abstract

Background: OXIDATIVE STRESS has been suggested to playa key role in accelerated atherosclerosis and to be involved in cardiovascular diseases of dialysis patients.Method: In this prospective study, we enrolled 34 (21 HEMODIALYSIS (HD) and 13 PERITONEAL DIALYSIS (PD)) patients. All of the subjects had received dialysis for at least 3 month. We also enrolled 18 normal controls (Ne). Serum levels ofmalondialdehyde (MDA) and thiobarbituric acid-reactive substances (TBARS) were used for measuring lipid peroxide levels. Also, commercial test kits were applied to estimate serum TOTAL ANTIOXIDANT STATUS. Results: MDA levels were significantly elevated in HD patients compared with NC group, 1.36 (0.00- 2.17) versus 0.00 (0.00-1.41) respectively (P=0.005); while there was not a significant difference with regard to MDA between PD patients 0.88 (0.00-14.8) and NC group. Also, there were significant differences in serum TAS between RD, PD patients and NC group (1.44(1.09-1.63), 1.31(1.08- 1.54) and 1.17(1.06-1.43), respectively, (p=0.001)). In addition, we found that TAS concentration was significantly correlated with serum MDA level in HD and PD patients (r= 0.443, P<0.001). Conclusion: The results of our study showed that in spite of elevated serum levels of TAS, the susceptibility to OXIDATIVE STRESS is related to MDA levels.

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APA: Copy

SEYEDREZAZADEH, E., ARDALAN, M.R., & POURMOGHADAM, M.. (2008). SERUM LIPID PEROXIDATION AND TOTAL ANTIOXIDANT STATUS IN HEMODIALYSIS AND CONTINUOUS AMBULATORY PERITONEAL DIALYSIS PATIENTS. JOURNAL OF MEDICAL COUNCIL OF I.R.I., 25(4), 497-504. SID. https://sid.ir/paper/41027/en

Vancouver: Copy

SEYEDREZAZADEH E., ARDALAN M.R., POURMOGHADAM M.. SERUM LIPID PEROXIDATION AND TOTAL ANTIOXIDANT STATUS IN HEMODIALYSIS AND CONTINUOUS AMBULATORY PERITONEAL DIALYSIS PATIENTS. JOURNAL OF MEDICAL COUNCIL OF I.R.I.[Internet]. 2008;25(4):497-504. Available from: https://sid.ir/paper/41027/en

IEEE: Copy

E. SEYEDREZAZADEH, M.R. ARDALAN, and M. POURMOGHADAM, “SERUM LIPID PEROXIDATION AND TOTAL ANTIOXIDANT STATUS IN HEMODIALYSIS AND CONTINUOUS AMBULATORY PERITONEAL DIALYSIS PATIENTS,” JOURNAL OF MEDICAL COUNCIL OF I.R.I., vol. 25, no. 4, pp. 497–504, 2008, [Online]. Available: https://sid.ir/paper/41027/en

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