ASSESSMENT OF SERUM TRANSFERRIN RECEPTOR (STR) LEVELS IN NORMAL AND ADULT Β THALASSEMIA MAJOR PATIENTS

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PASALAR P.; HADIPOUR M.

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Journal: Journal of Medical Council of Iran Year:2003 | Volume:20 | Issue:4 Page(s): 288-291

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Title

ASSESSMENT OF SERUM TRANSFERRIN RECEPTOR (STR) LEVELS IN NORMAL AND ADULT Β THALASSEMIA MAJOR PATIENTS

Author(s)

PASALAR P. | HADIPOUR M. | Issue Writer Certificate

Keywords

TRANSFERRIN RECEPTORQ4

Β; THALASSEMIA MAJORQ4

INEFFECTIVE ERYTHROPOIESISQ4

Abstract

Transferrin is an iron carrier in blood stream and iron binding to it takes place through a specific membrane receptor at the cellular level. A small amount of the external portion of the receptor is cleaved and released in to the blood. This protion is called soluble TRANSFERRIN RECEPTOR (STR). STR is increased in Iron deficiency Anemia and decreased in Acute Iron poisoning. To consider the value of STR measurement in determination of Iron overload in β thalassemia, STR levels were determined in 56 thalassemia patients and 23 apperantly healthy volunteers, by ELISA method. Results were compared by T-student test. The mean values of STR in case and control were 8.06±0.45mg/l and 1.5±0.17mg/I respectively. The means showed a significant difference (P<0.0001).Then the cases were divided in to two groups on the basis of having regular or irregular blood transfusion. The mean values for STR levels were 6.70±0.73mg/I and 9.42±0.76 mg/I respectively, which did not show a significant difference(P=0.45).STR level is proportional to the ineffective erythropoesis in thalassemic patients, so regular blood transfusion is a method to reduce ineffective erythrnpoesis and prevention of its side effects such as abnormal growth of bones and osteoporosis, but because there is not any significant difference between the two thalassemic patients groups, we may conclude that they have not such a big difference in the ineffective erythropoesis.

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APA: Copy

PASALAR, P., & HADIPOUR, M.. (2003). ASSESSMENT OF SERUM TRANSFERRIN RECEPTOR (STR) LEVELS IN NORMAL AND ADULT Β THALASSEMIA MAJOR PATIENTS. JOURNAL OF MEDICAL COUNCIL OF I.R.I., 20(4), 288-291. SID. https://sid.ir/paper/41243/en

Vancouver: Copy

PASALAR P., HADIPOUR M.. ASSESSMENT OF SERUM TRANSFERRIN RECEPTOR (STR) LEVELS IN NORMAL AND ADULT Β THALASSEMIA MAJOR PATIENTS. JOURNAL OF MEDICAL COUNCIL OF I.R.I.[Internet]. 2003;20(4):288-291. Available from: https://sid.ir/paper/41243/en

IEEE: Copy

P. PASALAR, and M. HADIPOUR, “ASSESSMENT OF SERUM TRANSFERRIN RECEPTOR (STR) LEVELS IN NORMAL AND ADULT Β THALASSEMIA MAJOR PATIENTS,” JOURNAL OF MEDICAL COUNCIL OF I.R.I., vol. 20, no. 4, pp. 288–291, 2003, [Online]. Available: https://sid.ir/paper/41243/en

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