Introduction of Chromosomally integrated human herpesvirus 6 and its clinical implications

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KETABI KIANA; Shatizadeh Malekshahi Soamyeh

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Journal Paper

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Journal: Pathobiology Research Year:2020 | Volume:23 | Issue:4 Page(s): 55-66

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Information Journal Paper

Title

Introduction of Chromosomally integrated human herpesvirus 6 and its clinical implications

Author(s)

KETABI KIANA | Shatizadeh Malekshahi Soamyeh | Issue Writer Certificate

Keywords

Human Herpesvirus 6Q1

IntegrationQ1

TelomersQ1

ciHHV-6Q1

Abstract

Aims: Human herpes virus 6 (HHV-6) is a ubiquitous virus with a high rate of prevalence worldwide. In recent years, a new form of the virus genome has been identified called chromosomally integrated HHV-6 (ciHHV6). Further studies are required to elucidate the relation between ciHHV-6 and other clinical complications. The purpose of this study was to summarize the literature on different clinical aspects of the ciHHV-6 Integration and its prevalevce in different communities. Materials and methods: Search keywords include HHV-6, integrated genome, telomeric regions and integrated HHV-6. Scientific databases such as scopus, PubMed and google scholar with no specified start date were used for information collection. Findings: About 1% of global populations are infected with ciHHV-6. Real-time PCR can be used to differentiate between ciHHV-6 and HHV-6 acute infection in which the viral load will be higher in ciHHV-6 compared to the acute infection. However, ciHHV-6 can be confirmed by evidence of one copy of viral DNA in hair or nail follicles. It has been shown that ciHHV-6 may disrupt the telomer stability. Conclutions: To date, no treatment has been discovered to remove the viral genome from the host cells. Taken together, the integrated form of the HHV-6 genome could be linked to the various diseases, including heart and autoimmune diseases. But further studies are needed to find its association with other diseases in different geographic area.

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APA: Copy

KETABI, KIANA, & Shatizadeh Malekshahi, Soamyeh. (2020). Introduction of Chromosomally integrated human herpesvirus 6 and its clinical implications. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 23(4 ), 55-66. SID. https://sid.ir/paper/412452/en

Vancouver: Copy

KETABI KIANA, Shatizadeh Malekshahi Soamyeh. Introduction of Chromosomally integrated human herpesvirus 6 and its clinical implications. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2020;23(4 ):55-66. Available from: https://sid.ir/paper/412452/en

IEEE: Copy

KIANA KETABI, and Soamyeh Shatizadeh Malekshahi, “Introduction of Chromosomally integrated human herpesvirus 6 and its clinical implications,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 23, no. 4 , pp. 55–66, 2020, [Online]. Available: https://sid.ir/paper/412452/en

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