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Information Journal Paper

Title

Effect of metformin on the expression of SNARE proteins in the skeletal muscle of rats with type 2 diabetes

Pages

  270-278

Abstract

 Background and Aims: SNARE proteins are composed of a combination of SNAP-23, Stx-4, and VAMP-2 isoforms that are significantly expressed in skeletal muscle. These proteins control the transport of GLUT4 to the cell membranes. The modifications in the expression of SNARE proteins can cause Type 2 diabetes. The present study aimed to assess the effect of Metformin on the expression of these proteins in rats. Materials and Methods: For the purpose of the study, 40 male Wistar rats were randomly selected. Streptozotocin and Nicotinamide were used for the induction of Type 2 diabetes. The animals were assigned to five groups (n=8), including healthy and diabetic groups as control, as well as three experimental groups which were treated with different doses of Metformin (100, 150, and 200 mg/kg body weight) for 30 days. The quantitative reverse transcription PCR (RT-qPCR) method was applied to evaluate the expression of SNARE complex proteins. Results: Based on the results, Metformin (100, 150, and 200 mg/kg body weight) decreased serum glucose levels and increased serum insulin levels. This difference in dose of 200 mg/kg body weight was statistically significant (P<0. 05). Moreover, all three doses of Metformin increased the expression of SNAP-23, syntaxin-4, and VAMP-2 proteins in skeletal muscle tissue. Metformin at a dose of 200 mg/kg body weight demonstrated the most significant effects (P<0. 05). Conclusion: As evidenced by the results of the current study, another anti-diabetic mechanism of Metformin is to increase the expression of SNARE proteins, which effectively improves insulin resistance and lowers blood glucose.

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    Cite

    APA: Copy

    MOHAMMADI, YASER, & REZAEI FARIMANI, AZAM. (2021). Effect of metformin on the expression of SNARE proteins in the skeletal muscle of rats with type 2 diabetes. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, 28(3 ), 270-278. SID. https://sid.ir/paper/412558/en

    Vancouver: Copy

    MOHAMMADI YASER, REZAEI FARIMANI AZAM. Effect of metformin on the expression of SNARE proteins in the skeletal muscle of rats with type 2 diabetes. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2021;28(3 ):270-278. Available from: https://sid.ir/paper/412558/en

    IEEE: Copy

    YASER MOHAMMADI, and AZAM REZAEI FARIMANI, “Effect of metformin on the expression of SNARE proteins in the skeletal muscle of rats with type 2 diabetes,” JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 3 , pp. 270–278, 2021, [Online]. Available: https://sid.ir/paper/412558/en

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