Effect of resveratrol on SNARE proteins expression and insulin resistance in skeletal muscle of diabetic rats

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

REZAEI FARIMANI AZAM; GOODARZI MOHAMMAD TAGHI; SAIDIJAM MASSOUD; YADEGARAZARI REZA; Zarei Sadegh; ASADI SOHEILA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2019 | Volume:22 | Issue:12 Page(s): 1408-1414

Download Full-Text

View:

129

Download:

131

Cites:

Information Journal Paper

Title

Effect of resveratrol on SNARE proteins expression and insulin resistance in skeletal muscle of diabetic rats

Author(s)

Keywords

Resveratrol

SNAP-23

SNARE complex proteins

Syntaxin-4

Type 2 diabetes

VAMP-2

Abstract

Objective(s): Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex proteins are involved in membrane trafficking. The expression of isoforms of SNAP-23, Syntaxin-4, and VAMP-2 is significantly done in skeletal muscles; they control GLUT4 trafficking. It is believed that Type 2 diabetes could be caused by the modifications in the expression of SNARE complex proteins. The purpose of this study was to evaluate the effect of Resveratrol on the expression of these proteins in Type 2 diabetes. Materials and Methods: Forty male Wistar rats were selected. Streptozotocin and nicotinamide were applied for the induction of Type 2 diabetes. The animals were divided into five groups. Healthy and diabetic groups were set as control; Resveratrol (1, 5, and 10 mg/kg body weight) was applied to treat the three groups of diabetic rats for 30 days. Real-time qRT-PCR was applied to evaluate the expression of SNARE complex proteins. Results: There is a link between diabetes and insulin resistance and up-regulation of SNARE proteins expression. Resveratrol improved hyperglycemia and insulin resistance along with a non-significant reduction in the expression of SNARE proteins. Conclusion: Increased expression of SNARE proteins was possibly a compensatory mechanism in response to insulin resistance in the skeletal muscles of diabetic rats. Resveratrol non-significantly reduced the expression of SNARE proteins by enhancing insulin sensitivity, where this effect was dosedependent. Thus, higher doses of Resveratrol and longer intervention periods could probably be more effective. Another molecular mechanism of the anti-diabetic properties of Resveratrol was identified with an effect on the expression of SNARE proteins.

Cites

Effect of metformin on the expression of SNARE proteins in the skeletal muscle of rats with type 2 diabetes

References

Cite

APA: Copy

REZAEI FARIMANI, AZAM, GOODARZI, MOHAMMAD TAGHI, SAIDIJAM, MASSOUD, YADEGARAZARI, REZA, Zarei, Sadegh, & ASADI, SOHEILA. (2019). Effect of resveratrol on SNARE proteins expression and insulin resistance in skeletal muscle of diabetic rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(12), 1408-1414. SID. https://sid.ir/paper/753136/en

Vancouver: Copy

REZAEI FARIMANI AZAM, GOODARZI MOHAMMAD TAGHI, SAIDIJAM MASSOUD, YADEGARAZARI REZA, Zarei Sadegh, ASADI SOHEILA. Effect of resveratrol on SNARE proteins expression and insulin resistance in skeletal muscle of diabetic rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(12):1408-1414. Available from: https://sid.ir/paper/753136/en

IEEE: Copy

AZAM REZAEI FARIMANI, MOHAMMAD TAGHI GOODARZI, MASSOUD SAIDIJAM, REZA YADEGARAZARI, Sadegh Zarei, and SOHEILA ASADI, “Effect of resveratrol on SNARE proteins expression and insulin resistance in skeletal muscle of diabetic rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 12, pp. 1408–1414, 2019, [Online]. Available: https://sid.ir/paper/753136/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops