COMPARISON BETWEEN TWO RANDOMIZED,CONTROLLED STRATIGIES IN ERADICATION OF HELICO BACTER PYLORI IN IRANIAN PATIENTS WITH DUODENAL ULCER

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SOTOUDEHMANESH R.; MALEKZADEH R.; MASARAT S.; ZIAD ALI ZADEH B.; ESHRAGHIAN M.R.

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Journal: Journal of Medical Council of Iran Year:2000 | Volume:18 | Issue:1 Page(s): 5-10

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Title

COMPARISON BETWEEN TWO RANDOMIZED,CONTROLLED STRATIGIES IN ERADICATION OF HELICO BACTER PYLORI IN IRANIAN PATIENTS WITH DUODENAL ULCER

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Keywords

HELICOBACTCR PYLORI. PEPTIC ULCERQ3

METRONIDAZOLE RESISTANCEQ3

Abstract

Previous studies have clearly shown that 2 weeks standard triple (Metronidazole + Bismuth + Tetracycline) or ranitidine + triple therapy (RMBT) always resulted in eradication of <80% in Iranian HP infected DU Patients. This is probably due to Metronidazole resistant rate of >40% in our DU Patients. The aim of this study was to compare 2 weeks clarithromycin - based regimen (Clarithroiycin + Bismuth + Tdracycline + Omeprazole= DCBT) with 2 or 3 weeks RMBT therapy and to elucidate which strategies. prolongation of treatment. Duration or replacement of Metronidazole by Clarithromycin) ,are more efficacious in HP eradication in DU patients in Iran.221 Patients with endoscopically proven DU ami positive rapid urease test in biopsy specimens presenting consecutively over;, 6 months period, were randomly allocated to three groups and recleved following regimens: A Omeprazole 2X20 mg, Clarithromycin 2x20 mg. Bismuth subcitrate 2X240 mg and Tetracycline 2X500 mg daily for Two weeks (OCBT). B: Ranitidine 2X300 mg. Bismuth subcitrate 2X240 mg, Metronidazole 2X500 mg and Tetracycline 2X500 mg daily for two weeks (RMBT). C: the same regimen as B but for 3 weeks. Eradication of HP was assessed at least S weeks after the completion of therapy with C 14 - urea breath test (UBT). The patients underwent a second endoscopy only if they had a positive UBT or were still symptomatic.221 patients were enrolled, and 205 patients had completed the 8 weeks follow-up (67 in A, 6S in Band 70 in C). Demographic data and endoscopic findings were comparable in all groups. Compliance was good with only one dropout in group B and one in C. Significant side effects were reported by 6.4%, of patients in A 17.7% in Band 14.2% in C; all of them were tolerable. Per protocol eradication rates of H. Pylori were as following: A (88.1%) higher than B (73.5 %) and C (71.4%) (A Versus B or C P<0.0). Eradication rates by intention to treat were as following: A (79.7%). B (67.65%) and C (68.5%).Prolongation of Ranitidinc + triple therapy from 2 to 3 weeks does not result in higher eradication rate of H.Pylori. Replacement of Metronidazole by Clarithromycin in OCBT regimen is clearly better than 2 or 3 weeks quadruple therapy, The 2 week OCBT therapy with 88.1% eradication rate by per protocol analysis in Iranian DU patients is still not the optimal and effective regimen required for HP eradication in other countries

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APA: Copy

SOTOUDEHMANESH, R., MALEKZADEH, R., MASARAT, S., ZIAD ALI ZADEH, B., & ESHRAGHIAN, M.R.. (2000). COMPARISON BETWEEN TWO RANDOMIZED,CONTROLLED STRATIGIES IN ERADICATION OF HELICO BACTER PYLORI IN IRANIAN PATIENTS WITH DUODENAL ULCER. JOURNAL OF MEDICAL COUNCIL OF I.R.I., 18(1), 5-10. SID. https://sid.ir/paper/41283/en

Vancouver: Copy

SOTOUDEHMANESH R., MALEKZADEH R., MASARAT S., ZIAD ALI ZADEH B., ESHRAGHIAN M.R.. COMPARISON BETWEEN TWO RANDOMIZED,CONTROLLED STRATIGIES IN ERADICATION OF HELICO BACTER PYLORI IN IRANIAN PATIENTS WITH DUODENAL ULCER. JOURNAL OF MEDICAL COUNCIL OF I.R.I.[Internet]. 2000;18(1):5-10. Available from: https://sid.ir/paper/41283/en

IEEE: Copy

R. SOTOUDEHMANESH, R. MALEKZADEH, S. MASARAT, B. ZIAD ALI ZADEH, and M.R. ESHRAGHIAN, “COMPARISON BETWEEN TWO RANDOMIZED,CONTROLLED STRATIGIES IN ERADICATION OF HELICO BACTER PYLORI IN IRANIAN PATIENTS WITH DUODENAL ULCER,” JOURNAL OF MEDICAL COUNCIL OF I.R.I., vol. 18, no. 1, pp. 5–10, 2000, [Online]. Available: https://sid.ir/paper/41283/en

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